Healthy limb joints are important for maintaining health and attaining longevity.
Endochondral ossification (the replacement of cartilage with bone, occurring during skeletal …

Osteoarthritis (OA) and rheumatoid arthritis (RA) are both debilitating diseases that cause
significant morbidity in the US population. Extracellular vesicles (EVs), including exosomes …

Articular cartilage has limited self-regenerative capacity and the therapeutic methods for
cartilage defects are still dissatisfactory in clinic. Recent studies showed that exosomes …

Circular RNAs (circRNAs) are involved in the development of various diseases, but there is
little knowledge of circRNAs in osteoarthritis (OA). The aim of study was to identify circRNA …

Abstract Histone deacetylase 3 (HDAC3) plays a pivotal role in the repression of cartilage-
specific gene expression in human chondrocytes. The aim of this study was to determine …

Summary Objective Metalloproteinases (MMPs) are key regulators of osteoarthritis (OA) and
collagen degradation and have been shown to participate in endochondral ossification. The …

It is believed that endometrial miRNAs contribute to the aetiology of endometriosis in stem
cells; however, the mechanisms remain unclear. Here we collected serum samples from …

The aim of the current study was to compare the expression of microRNAs (miRNAs) in
exosomes derived from human bone mesenchymal stem cells (hBMSCs) with and without …

Summary Objectives Long noncoding RNAs (lncRNAs) have emerged as a novel class of
regulatory molecules involved in various biological processes, but their role in osteoarthritis …

Defects of articular cartilage present a unique clinical challenge due to its poor self-healing
capacity and avascular nature. Current surgical treatment options do not ensure consistent …