The intricacy of diseases, shaped by intrinsic processes like immune system exhaustion and
hyperactivation, highlights the potential of immune renormalization as a promising strategy …

TCF1 and its homologue LEF1 are historically known as effector transcription factors
downstream of the WNT signalling pathway and are essential for early T cell development …

The ontogeny of human haematopoietic stem cells (HSCs) is poorly defined owing to the
inability to identify HSCs as they emerge and mature at different haematopoietic sites. Here …

Azvudine (FNC) is a nucleoside analog that inhibits HIV-1 RNA-dependent RNA polymerase
(RdRp). Recently, we discovered FNC an agent against SARS-CoV-2, and have taken it into …

INTRODUCTION The thymus is the critical organ for T cell development and T cell receptor
(TCR) repertoire formation, which shapes the landscape of adaptive immunity. T cell …

Macrophages are the first cells of the nascent immune system to emerge during embryonic
development. In mice, embryonic macrophages infiltrate developing organs, where they …

Single-cell genomics studies have decoded the immune cell composition of several human
prenatal organs but were limited in describing the developing immune system as a …

Clinical genetics has an important role in the healthcare system to provide a definitive
diagnosis for many rare syndromes. It also can have an influence over genetics prevention …

The thymus' key function in the immune system is to provide the necessary environment for
the development of diverse and self-tolerant T lymphocytes. While recent evidence suggests …

Hematopoiesis has long served as a paradigm of stem cell biology and tissue homeostasis.
In the past decade, the genomics revolution has ushered in powerful new methods for …