It has been known for more than 60 years, and suspected for over 100, that alveolar hypoxia
causes pulmonary vasoconstriction by means of mechanisms local to the lung. For the last …

The calcium ion (Ca2+) is the simplest and most versatile intracellular messenger known.
The discovery of Ca2+ sparks and a related family of elementary Ca2+ signaling events has …

Calcium is a ubiquitous second messenger used to regulate a wide range of cellular
processes. This role in signalling has to be conducted against the rigid homeostatic …

Excitation contraction (ec) coupling in skeletal and cardiac muscles involves an interaction
between specialized junctional domains of the sarcoplasmic reticulum (SR) and of exterior …

The control of calcium release from intracellular stores (the sarcoplasmic reticulum) in
cardiac muscle was examined with the use of a confocal microscope and voltage clamp …

Triggered activity in cardiac muscle and intracellular Ca2+ have been linked in the past.
However, today not only are there a number of cellular proteins that show clear Ca2+ …

Excitation-contraction coupling was studied in mammalian cardiac cells in which the
opening probability of L-type calcium (Ca2+) channels was reduced. Confocal microscopy …

The cardiac action potential (AP) is critical for initiating and coordinating myocyte
contraction. In particular, the early repolarization period of the AP (phase 1) strongly …

The role of intracellular Ca2+ (Ca12+) in triggering early afterdepolarizations (EADs), the
origins of EADs and the mechanisms underlying Torsade de Pointes (TdP) were …

Determination of the calcium spark amplitude distribution is of critical importance for
understanding the nature of elementary calcium release events in striated muscle. In the …