The renin-angiotensin-aldosterone system (RAAS), is an old system with new fundamental
roles in cancer biology which influences cell growth, migration, death, and metastasis. RAAS …

Day by day, the health and economical burden of cancer increases globally. Indeed it can
be considered that there is ''cancer pandemic''. Blocking the renin-angiotensin system (RAS) …

The link between psychological stress and aging is intuitive although the underlying
mechanisms are not well defined. Evidence suggests that chronic psychological stress …

The sigma receptors were classified into sigma-1 and sigma-2 receptor based on their
different pharmacological profiles. In the past two decades, our understanding of the …

Targeting androgen receptor (AR) by pharmacologic intervention is one of the effective
approaches for treatment of malignant prostate cancers. Histone deacetylase (HDAC) alters …

Drug repurposing is a promising way in drug discovery to identify new therapeutic uses–
different from the original medical indication–for existing drugs. It has many advantages over …

Cholangiocarcinoma (CCA) is a destructive malignancy with limited responsiveness to
conventional chemotherapy. Although angiotensin receptor blockers (ARBs) have gained …

Emerging evidence suggests that renin-angiotensin system (RAS) may act as a molecular
and therapeutic target for treating site-specific cancers, including prostate cancer. However …

It has been well-characterized that the renin-angiotensin system (RAS) physiologically
regulates systemic arterial pressure. However, RAS signaling has also been shown to …

Angiotensin II receptor type 1 blockers (ARBs), widely used antihypertensive drugs, have
also been investigated for their anticancer effects. The effect of ARBs on prostate cancer in …