In vitro modelling the complex (patho‐) physiological conditions of the heart is a major
challenge in cardiovascular research. In recent years, methods based on three‐dimensional …

Introduction Human induced pluripotent stem cell (iPSC)-derived cardiomyocytes is one of
the most widely used cell-based models that resulted from the discovery of how non …

Drug-induced cardiotoxicity not only leads to the attrition of drugs during development, but
also contributes to the high morbidity and mortality rates of cardiovascular diseases …

Background: We hypothesize that the poor survival outcomes of end-stage kidney disease
(ESKD) patients undergoing hemodialysis are associated with a low filtering efficiency and …

Anthracyclines are a class of chemotherapy drugs that are highly effective for the treatment
of human cancers, but their clinical use is limited by associated dose-dependent …

Oncotherapeutics research is progressing at a rapid pace, however, not many drugs
complete the successful clinical trial because of severe off-target toxicity to cardiomyocytes …

Proper protein glycosylation is critical to normal cardiomyocyte physiology. Aberrant
glycosylation can alter protein localization, structure, drug interactions, and cellular function …

Cardiovascular research has heavily relied on studies using patient samples and animal
models. However, patient studies often miss the data from the crucial early stage of …