Mesenchymal stem cells (MSCs) are multipotent cells with a substantial potential in human
regenerative medicine due to their ability to migrate to sites of injury, capability to suppress …

Platelets play an essential role in maintaining homeostasis in the circulatory system after an
injury by forming a platelet thrombus, but they also occupy a central node in the …

The existence of extracellular phosphoproteins has been acknowledged for over a century.
However, research in this area has been undeveloped largely because the kinases that …

Protein phosphorylation is a fundamental mechanism regulating nearly every aspect of
cellular life. Several secreted proteins are phosphorylated, but the kinases responsible are …

Human blood plasma can be obtained relatively noninvasively and contains proteins from
most, if not all, tissues of the body. Therefore, an extensive, quantitative catalog of plasma …

Peptide identification via tandem mass spectrometry sequence database searching is a key
method in the array of tools available to the proteomics researcher. The ability to rapidly and …

Mass spectrometry-based studies of proteins that are post-translationally modified by O-
linked β-N-acetylglucosamine (O-GlcNAc) are challenged in effectively identifying the sites …

Although numerous extracellular phosphoproteins have been identified, the protein kinases
within the secretory pathway have only recently been discovered, and their regulation is …

Fam20C is a kinase that generates the majority of secreted phosphoproteins and regulates
biomineralization. However, its potential roles in bone resorption and breast cancer bone …

In the last decade, proteomic technologies have been increasingly used in fish biology
research. Proteomics has been applied primarily to investigate the physiology, development …