Control of DNA replication timing in the 3D genome
The 3D organization of mammalian chromatin was described more than 30 years ago by
visualizing sites of DNA synthesis at different times during the S phase of the cell cycle …
visualizing sites of DNA synthesis at different times during the S phase of the cell cycle …
CTCF and cohesin in genome folding and transcriptional gene regulation
M Merkenschlager, EP Nora - Annual review of genomics and …, 2016 - annualreviews.org
Genome function, replication, integrity, and propagation rely on the dynamic structural
organization of chromosomes during the cell cycle. Genome folding in interphase provides …
organization of chromosomes during the cell cycle. Genome folding in interphase provides …
3D structures of individual mammalian genomes studied by single-cell Hi-C
The folding of genomic DNA from the beads-on-a-string-like structure of nucleosomes into
higher-order assemblies is crucially linked to nuclear processes. Here we calculate 3D …
higher-order assemblies is crucially linked to nuclear processes. Here we calculate 3D …
The impact of replication stress on replication dynamics and DNA damage in vertebrate cells
H Técher, S Koundrioukoff, A Nicolas… - Nature Reviews …, 2017 - nature.com
The interplay between replication stress and the S phase checkpoint is a key determinant of
genome maintenance, and has a major impact on human diseases, notably, tumour …
genome maintenance, and has a major impact on human diseases, notably, tumour …
4D genome rewiring during oncogene-induced and replicative senescence
To understand the role of the extensive senescence-associated 3D genome reorganization,
we generated genome-wide chromatin interaction maps, epigenome, replication-timing …
we generated genome-wide chromatin interaction maps, epigenome, replication-timing …
[HTML][HTML] Identifying cis elements for spatiotemporal control of mammalian DNA replication
The temporal order of DNA replication (replication timing [RT]) is highly coupled with
genome architecture, but cis-elements regulating either remain elusive. We created a series …
genome architecture, but cis-elements regulating either remain elusive. We created a series …
Replication timing maintains the global epigenetic state in human cells
The temporal order of DNA replication [replication timing (RT)] is correlated with chromatin
modifications and three-dimensional genome architecture; however, causal links have not …
modifications and three-dimensional genome architecture; however, causal links have not …
RIF1 promotes replication fork protection and efficient restart to maintain genome stability
C Mukherjee, V Tripathi, EM Manolika… - Nature …, 2019 - nature.com
Homologous recombination (HR) and Fanconi Anemia (FA) pathway proteins in addition to
their DNA repair functions, limit nuclease-mediated processing of stalled replication forks …
their DNA repair functions, limit nuclease-mediated processing of stalled replication forks …
Lamina-associated domains: Tethers and looseners
Lamina-associated domains (LADs) are large heterochromatic regions that are positioned at
the nuclear lamina (NL). A major question is how LAD–NL interactions are mediated and …
the nuclear lamina (NL). A major question is how LAD–NL interactions are mediated and …
53BP1 nuclear bodies enforce replication timing at under-replicated DNA to limit heritable DNA damage
J Spies, C Lukas, K Somyajit, MB Rask, J Lukas… - Nature cell …, 2019 - nature.com
Failure to complete DNA replication is a stochastic by-product of genome doubling in almost
every cell cycle. During mitosis, under-replicated DNA (UR-DNA) is converted into DNA …
every cell cycle. During mitosis, under-replicated DNA (UR-DNA) is converted into DNA …