Abstract The Coronavirus Disease 2019 (COVID-19) pandemic has become a global crisis
and is more devastating than any other previous infectious disease. It has affected a …

Background In the current SARS-CoV-2 pandemic, there has been worldwide debate on the
use of corticosteroids in COVID-19. In the recent RECOVERY trial, evaluating the effect of …

It has been reported that corticosteroid therapy was effective in the management of severe
acute respiratory syndrome (SARS) and the Middle East Respiratory Syndrome (MERS) …

As the pandemic progresses, the pathophysiology of coronavirus disease 2019 (COVID‐19)
is becoming clearer and the potential for immunotherapy is increasing. However, clinical …

Background There is accumulating evidence for an overly activated immune response in
severe COVID-19, with several studies exploring the therapeutic role of immunomodulation …

Acting on the cytokine cascade is key to preventing disease progression and death in
hospitalised patients with COVID-19. Among anti-cytokine therapies, interleukin (IL)-6 …

Importance Communication and adoption of modern study design and analytical techniques
is of high importance for the improvement of clinical research from observational data …

Before the coronavirus disease 2019 (COVID-19) pandemic, antimicrobial resistance was
the world's most pressing health crisis. The United Nations, the World Health Organization …

Background Currently, the data regarding the effectiveness and safety of tocilizumab as
treatment for COVID-19 infection is still conflicting. This study aims to give clear evidence …

Tocilizumab has been repurposed against the 'cytokine storm'in the setting of coronavirus
disease 2019 (COVID‐19). Our aim was to evaluate the efficacy of tocilizumab in the …