Bioactive materials are a kind of materials with unique bioactivities, which can change the
cellular behaviors and elicit biological responses from living tissues. Bioactive materials …

Although the biological functions of cell and tissue can be regulated by biochemical factors
(eg, growth factors, hormones), the biophysical effects of materials on the regulation of …

The way in which a cell migrates is influenced by the physical properties of its surroundings,
in particular the properties of the extracellular matrix. How the physical aspects of the cell's …

Effective drug delivery is important in the treatment of various biomedical conditions, ranging
from autoimmune disorders to cancer and bacterial infections. Nanostructured systems can …

Topography of the extracellular environment is now recognized as a major biophysical
regulator of cell behavior and function. The study of the influence of patterned substrates on …

Bioprinting is a promising technique for engineering composite tissues, such as
osteochondral tissues. In this study, as a first step toward bioprinting-based osteochondral …

Defining the principles of T cell migration in structurally and mechanically complex tumor
microenvironments is critical to understanding escape from antitumor immunity and …

Spatiotemporal control of leukocyte dynamics within tissues is critical for successful innate
and adaptive immune responses. Homeostatic trafficking and coordinated infiltration into …

Both substrate stiffness and surface topography regulate cell behavior through
mechanotransduction signaling pathways. Such intertwined effects suggest that engineered …

We investigate the effects of surface nanotopography on the migration and cell shape
dynamics of the amoeba Dictyostelium discoideum. Multiple prior studies have implicated …