Multidrug resistance (MDR): A widespread phenomenon in pharmacological therapies

A Catalano, D Iacopetta, J Ceramella, D Scumaci… - Molecules, 2022 - mdpi.com
Multidrug resistance is a leading concern in public health. It describes a complex phenotype
whose predominant feature is resistance to a wide range of structurally unrelated cytotoxic …

Multidrug resistance in cancer: understanding molecular mechanisms, immunoprevention and therapeutic approaches

TB Emran, A Shahriar, AR Mahmud, T Rahman… - Frontiers in …, 2022 - frontiersin.org
Cancer is one of the leading causes of death worldwide. Several treatments are available for
cancer treatment, but many treatment methods are ineffective against multidrug-resistant …

Dissecting tumor growth: the role of cancer stem cells in drug resistance and recurrence

B Aramini, V Masciale, G Grisendi, F Bertolini, M Maur… - Cancers, 2022 - mdpi.com
Simple Summary Cancer is one of the most debated problems all over the world. Cancer
stem cells are considered responsible of tumor initiation, metastasis, drug resistance, and …

New challenges in the use of nanomedicine in cancer therapy

M Rasool, A Malik, S Waquar, M Arooj, S Zahid… - …, 2022 - Taylor & Francis
Nanomedicines are applied as alternative treatments for anticancer agents. For the
treatment of cancer, due to the small size in nanometers (nm), specific site targeting can be …

Exosome-based cancer therapy: implication for targeting cancer stem cells

J Wang, Y Zheng, M Zhao - Frontiers in pharmacology, 2017 - frontiersin.org
Drug resistance, difficulty in specific targeting and self-renewal properties of cancer stem
cells (CSCs) all contribute to cancer treatment failure and relapse. CSCs have been …

Progress in nanomedicine-based drug delivery in designing of chitosan nanoparticles for cancer therapy

MZ Ahmad, M Rizwanullah, J Ahmad… - … Journal of Polymeric …, 2022 - Taylor & Francis
Cancer is among the most dreadful fatal diseases globally, and the efficacy of recent
chemotherapeutic approaches is limited due to many related drawbacks. The major …

Nanotherapeutics approaches to overcome P-glycoprotein-mediated multi-drug resistance in cancer

J Halder, D Pradhan, B Kar, G Ghosh, G Rath - … , Biology and Medicine, 2022 - Elsevier
Multidrug resistance (MDR) in cancer chemotherapy is a growing concern for medical
practitioners. P-glycoprotein (P-gp) overexpression is one of the major reasons for multidrug …

Progress of cancer nanotechnology as diagnostics, therapeutics, and theranostics nanomedicine: preclinical promise and translational challenges

S Alshehri, SS Imam, M Rizwanullah, S Akhter… - Pharmaceutics, 2020 - mdpi.com
Early detection, right therapeutic intervention, and simultaneous effectiveness mapping are
considered the critical factors in successful cancer therapy. Nevertheless, these factors …

The therapeutic potential of targeting ABC transporters to combat multi-drug resistance

P Bugde, R Biswas, F Merien, J Lu, DX Liu… - Expert opinion on …, 2017 - Taylor & Francis
Introduction: Most disseminated cancers remain fatal despite the availability of a variety of
conventional and novel treatments including surgery, chemotherapy, radiotherapy …

Cancer therapy based on extracellular vesicles as drug delivery vehicles

L Cabeza, G Perazzoli, M Peña, A Cepero… - Journal of controlled …, 2020 - Elsevier
Extracellular vesicles (EVs) are lipid bilayer vesicles of nanometric size secreted by cells to
communicate with other cells, either nearby or remotely. Their physicochemical properties …