Behavioural and psychological symptoms of dementia in mouse models of Alzheimer's disease-related pathology
F Kosel, JMS Pelley, TB Franklin - Neuroscience & Biobehavioral Reviews, 2020 - Elsevier
Transgenic mouse models have been used extensively to model the cognitive impairments
arising from Alzheimer's disease (AD)-related pathology. However, less is known about the …
arising from Alzheimer's disease (AD)-related pathology. However, less is known about the …
[HTML][HTML] Rodent models of amyloid-beta feature of Alzheimer's disease: Development and potential treatment implications
Alzheimer's disease (AD) is the most common neurodegenerative disorder worldwide and
causes severe financial and social burdens. Despite much research on the pathogenesis of …
causes severe financial and social burdens. Despite much research on the pathogenesis of …
Comparison of memory, affective behavior, and neuropathology in APPNLGF knock-in mice to 5xFAD and APP/PS1 mice
A Locci, H Orellana, G Rodriguez, M Gottliebson… - Behavioural brain …, 2021 - Elsevier
Transgenic mouse models of Aβ amyloidosis generated by knock-in of a humanized Aβ
sequence can offer some advantages over the transgenic models that overexpress amyloid …
sequence can offer some advantages over the transgenic models that overexpress amyloid …
[HTML][HTML] Significance of native PLGA nanoparticles in the treatment of Alzheimer's disease pathology
Alzheimer's disease (AD) is believed to be triggered by increased levels/aggregation of β-
amyloid (Aβ) peptides. At present, there is no effective disease-modifying treatment for AD …
amyloid (Aβ) peptides. At present, there is no effective disease-modifying treatment for AD …
MMP9 modulation improves specific neurobehavioral deficits in a mouse model of Alzheimer's disease
C Ringland, JE Schweig, M Eisenbaum, D Paris… - BMC neuroscience, 2021 - Springer
Abstract Background Matrix metallopeptidase 9 (MMP9) has been implicated in a variety of
neurological disorders, including Alzheimer's disease (AD), where MMP9 levels are …
neurological disorders, including Alzheimer's disease (AD), where MMP9 levels are …
Cognitive decline and BPSD are concomitant with autophagic and synaptic deficits associated with G9a alterations in aged SAMP8 mice
F Vasilopoulou, A Bellver-Sanchis… - Cells, 2022 - mdpi.com
Behavioural and psychological symptoms of dementia (BPSD) are presented in 95% of
Alzheimer's Disease (AD) patients and are also associated with neurotrophin deficits. The …
Alzheimer's Disease (AD) patients and are also associated with neurotrophin deficits. The …
Sex differences in behavior and molecular pathology in the 5XFAD model
A Sil, A Erfani, N Lamb, R Copland… - Journal of …, 2022 - content.iospress.com
Background: The prevalence of Alzheimer's disease (AD) is greater in women compared to
men, but the reasons for this remain unknown. This sex difference has been widely …
men, but the reasons for this remain unknown. This sex difference has been widely …
Loss of SST and PV positive interneurons in the ventral hippocampus results in anxiety-like behavior in 5xFAD mice
H Li, J Zhao, L Lai, Y Xia, C Wan, S Wei, J Liang… - Neurobiology of …, 2022 - Elsevier
Neuropsychiatric symptoms, such as anxiety and depression often appear early in patients
with Alzheimer's disease (AD), and a comorbid, anxiety-like phenotype is also found in …
with Alzheimer's disease (AD), and a comorbid, anxiety-like phenotype is also found in …
Potential antidepressant effects of a dietary supplement from Huáng qí and its complex in aged senescence-accelerated mouse prone-8 mice
MY Chou, YC Wong, SY Wang, CH Chi… - Frontiers in …, 2023 - frontiersin.org
Healthcare is an emerging industry with significant market potential in the 21st century.
Therefore, this study aimed to evaluate the benefits of tube feeding Huáng qí and its …
Therefore, this study aimed to evaluate the benefits of tube feeding Huáng qí and its …
Characterization of apathy-like behaviors in the 5xFAD mouse model of Alzheimer's disease
R Keszycki, G Rodriguez, JT Dunn, A Locci… - Neurobiology of …, 2023 - Elsevier
Most patients with Alzheimer's disease (AD) develop neuropsychiatric symptoms (NPS)
alongside cognitive decline, and apathy is one of the most common symptoms. Few …
alongside cognitive decline, and apathy is one of the most common symptoms. Few …