As the culprit behind most cancer-related deaths, metastasis is the ultimate challenge in our
effort to fight cancer as a life-threatening disease. The explosive growth of metastasis …

Metastasis resistant to therapy is the major cause of death from cancer. Despite almost 200
years of study, the process of tumor metastasis remains controversial. Stephen Paget initially …

Systemic cancer progression is accounted for in two basic models. The prevailing archetype
places the engine of cancer progression within the primary tumour before metastatic …

Patients with cancer can develop recurrent metastatic disease with latency periods that
range from years even to decades. This pause can be explained by cancer dormancy, a …

Most cancer deaths are caused by haematogenous metastatic spread and subsequent
growth of tumour cells at distant organs. Disseminating tumour cells present in the …

Breast cancer is not a single disease, but rather is composed of distinct subtypes associated
with different clinical outcomes. Understanding this heterogeneity is key for the development …

Metastasis, the spread of malignant cells from a primary tumor to distant sites, poses the
biggest problem to cancer treatment and is the main cause of death of cancer patients. It …

Tumours contain immune cells and a network of pro-and anti-inflammatory cytokines, which
collaborate in the development and progression of cancer. Cytokine profiles might prove to …

Most cancer deaths are due to the development of metastases, hence the most important
improvements in morbidity and mortality will result from prevention (or elimination) of such …

Metastatic disease is the culmination of cancer and its most common life-threatening
manifestation. The highly complex process by which cancer cells disseminate to and …