[HTML][HTML] Regulation of microtubule dynamics, mechanics and function through the growing tip

NB Gudimchuk, JR McIntosh - Nature reviews Molecular cell biology, 2021 - nature.com
Microtubule dynamics and their control are essential for the normal function and division of
all eukaryotic cells. This plethora of functions is, in large part, supported by dynamic …

A microtubule bestiary: structural diversity in tubulin polymers

S Chaaban, GJ Brouhard - Molecular biology of the cell, 2017 - Am Soc Cell Biol
Microtubules are long, slender polymers of αβ-tubulin found in all eukaryotic cells. Tubulins
associate longitudinally to form protofilaments, and adjacent protofilaments associate …

[HTML][HTML] Phase separation of EB1 guides microtubule plus-end dynamics

X Song, F Yang, T Yang, Y Wang, M Ding, L Li… - Nature Cell …, 2023 - nature.com
In eukaryotes, end-binding (EB) proteins serve as a hub for orchestrating microtubule
dynamics and are essential for cellular dynamics and organelle movements. EB proteins …

Light-induced cell damage in live-cell super-resolution microscopy

S Wäldchen, J Lehmann, T Klein, S Van De Linde… - Scientific reports, 2015 - nature.com
Super-resolution microscopy can unravel previously hidden details of cellular structures but
requires high irradiation intensities to use the limited photon budget efficiently. Such high …

[HTML][HTML] Direct stochastic optical reconstruction microscopy with standard fluorescent probes

S Van de Linde, A Löschberger, T Klein… - Nature protocols, 2011 - nature.com
Direct stochastic optical reconstruction microscopy (d STORM) uses conventional
fluorescent probes such as labeled antibodies or chemical tags for subdiffraction resolution …

Mechanistic origin of microtubule dynamic instability and its modulation by EB proteins

R Zhang, GM Alushin, A Brown, E Nogales - Cell, 2015 - cell.com
Microtubule (MT) dynamic instability is driven by GTP hydrolysis and regulated by
microtubule-associated proteins, including the plus-end tracking end-binding protein (EB) …

An EB1-binding motif acts as a microtubule tip localization signal

S Honnappa, SM Gouveia, A Weisbrich, FF Damberger… - Cell, 2009 - cell.com
Microtubules are filamentous polymers essential for cell viability. Microtubule plus-end
tracking proteins (+ TIPs) associate with growing microtubule plus ends and control …

[HTML][HTML] EBs recognize a nucleotide-dependent structural cap at growing microtubule ends

SP Maurer, FJ Fourniol, G Bohner, CA Moores… - Cell, 2012 - cell.com
Growing microtubule ends serve as transient binding platforms for essential proteins that
regulate microtubule dynamics and their interactions with cellular substructures. End …

Microtubule-associated proteins control the kinetics of microtubule nucleation

M Wieczorek, S Bechstedt, S Chaaban… - Nature cell …, 2015 - nature.com
Microtubules are born and reborn continuously, even during quiescence. These polymers
are nucleated from templates, namely γ-tubulin ring complexes (γ-TuRCs) and severed …

[HTML][HTML] Self-repair promotes microtubule rescue

C Aumeier, L Schaedel, J Gaillard, K John… - Nature cell …, 2016 - nature.com
The dynamic instability of microtubules is characterized by slow growth phases
stochastically interrupted by rapid depolymerizations called catastrophes. Rescue events …