[HTML][HTML] Regulation of microtubule dynamics, mechanics and function through the growing tip
NB Gudimchuk, JR McIntosh - Nature reviews Molecular cell biology, 2021 - nature.com
Microtubule dynamics and their control are essential for the normal function and division of
all eukaryotic cells. This plethora of functions is, in large part, supported by dynamic …
all eukaryotic cells. This plethora of functions is, in large part, supported by dynamic …
A microtubule bestiary: structural diversity in tubulin polymers
S Chaaban, GJ Brouhard - Molecular biology of the cell, 2017 - Am Soc Cell Biol
Microtubules are long, slender polymers of αβ-tubulin found in all eukaryotic cells. Tubulins
associate longitudinally to form protofilaments, and adjacent protofilaments associate …
associate longitudinally to form protofilaments, and adjacent protofilaments associate …
[HTML][HTML] Phase separation of EB1 guides microtubule plus-end dynamics
X Song, F Yang, T Yang, Y Wang, M Ding, L Li… - Nature Cell …, 2023 - nature.com
In eukaryotes, end-binding (EB) proteins serve as a hub for orchestrating microtubule
dynamics and are essential for cellular dynamics and organelle movements. EB proteins …
dynamics and are essential for cellular dynamics and organelle movements. EB proteins …
Light-induced cell damage in live-cell super-resolution microscopy
S Wäldchen, J Lehmann, T Klein, S Van De Linde… - Scientific reports, 2015 - nature.com
Super-resolution microscopy can unravel previously hidden details of cellular structures but
requires high irradiation intensities to use the limited photon budget efficiently. Such high …
requires high irradiation intensities to use the limited photon budget efficiently. Such high …
[HTML][HTML] Direct stochastic optical reconstruction microscopy with standard fluorescent probes
S Van de Linde, A Löschberger, T Klein… - Nature protocols, 2011 - nature.com
Direct stochastic optical reconstruction microscopy (d STORM) uses conventional
fluorescent probes such as labeled antibodies or chemical tags for subdiffraction resolution …
fluorescent probes such as labeled antibodies or chemical tags for subdiffraction resolution …
Mechanistic origin of microtubule dynamic instability and its modulation by EB proteins
Microtubule (MT) dynamic instability is driven by GTP hydrolysis and regulated by
microtubule-associated proteins, including the plus-end tracking end-binding protein (EB) …
microtubule-associated proteins, including the plus-end tracking end-binding protein (EB) …
An EB1-binding motif acts as a microtubule tip localization signal
S Honnappa, SM Gouveia, A Weisbrich, FF Damberger… - Cell, 2009 - cell.com
Microtubules are filamentous polymers essential for cell viability. Microtubule plus-end
tracking proteins (+ TIPs) associate with growing microtubule plus ends and control …
tracking proteins (+ TIPs) associate with growing microtubule plus ends and control …
[HTML][HTML] EBs recognize a nucleotide-dependent structural cap at growing microtubule ends
Growing microtubule ends serve as transient binding platforms for essential proteins that
regulate microtubule dynamics and their interactions with cellular substructures. End …
regulate microtubule dynamics and their interactions with cellular substructures. End …
Microtubule-associated proteins control the kinetics of microtubule nucleation
Microtubules are born and reborn continuously, even during quiescence. These polymers
are nucleated from templates, namely γ-tubulin ring complexes (γ-TuRCs) and severed …
are nucleated from templates, namely γ-tubulin ring complexes (γ-TuRCs) and severed …
[HTML][HTML] Self-repair promotes microtubule rescue
The dynamic instability of microtubules is characterized by slow growth phases
stochastically interrupted by rapid depolymerizations called catastrophes. Rescue events …
stochastically interrupted by rapid depolymerizations called catastrophes. Rescue events …