HIV/AIDS is still a global threat despite the notable efforts made by the scientific and health
communities to understand viral infection, to design new drugs or to improve existing ones …

Integrase (IN) strand transfer inhibitors (INSTIs) are recent compounds in the antiretroviral
arsenal used against HIV. INSTIs work by blocking retroviral integration; an essential step in …

After the introduction of antiretroviral treatment (ART) back in 1996, the lifespan of people
living with HIV (PLWH) has been substantially increased, while the major causes of …

Over the past 60 years, more than 100 antiviral drugs or their combinations have been
approved for clinical use. Antiviral drugs can be classified according to their chemical nature …

Background: Today, HIV-1 infection has become an extensive problem to public health and
a greater challenge to all working researchers throughout the world. Since the beginning of …

During HIV-1 infection, the envelope glycoprotein subunit gp41 folds into a six-helix bundle
structure (6HB) formed by the interaction between its N-terminal (NHR) and C-terminal …

CC chemokine receptor 5 (CCR5) polymorphisms, particularly a 32-base pair deletion (∆ 32)
in the open reading frame and− 2459G> A in the promoter, are well known for their …

Latently infected CD 4+ T cells represent one of the major obstacles to HIV eradication even
after receiving prolonged highly active anti-retroviral therapy (HAART). Long-term use of …

Objectives: To identify potential compounds by seeking the knowledge of molecular
interactions between human immunodeficiency virus (HIV) glycoprotein (gp) 120 protein and …

Background: Although current available medications have increased the quality of life in HIV-
infected patients, there are still some shortcomings in HIV treatment arising from viral …