The molecular pathophysiology of depression and the new therapeutics

H Tian, Z Hu, J Xu, C Wang - MedComm, 2022 - Wiley Online Library
Major depressive disorder (MDD) is a highly prevalent and disabling disorder. Despite the
many hypotheses proposed to understand the molecular pathophysiology of depression, it is …

Imaging synaptic density: the next holy grail of neuroscience?

ME Serrano, E Kim, MM Petrinovic… - Frontiers in …, 2022 - frontiersin.org
The brain is the central and most complex organ in the nervous system, comprising billions
of neurons that constantly communicate through trillions of connections called synapses …

Understanding the role of oxidative stress, neuroinflammation and abnormal myelination in excessive aggression associated with depression: recent input from …

A Gorlova, E Svirin, D Pavlov, R Cespuglio… - International journal of …, 2023 - mdpi.com
Aggression and deficient cognitive control problems are widespread in psychiatric disorders,
including major depressive disorder (MDD). These abnormalities are known to contribute …

Chronic social defeat stress mouse model: Current view on its behavioral deficits and modifications.

W Wang, W Liu, D Duan, H Bai, Z Wang… - Behavioral …, 2021 - psycnet.apa.org
Stress is the main cause of mood disorders such as depression and posttraumatic stress
disorder. Individuals respond to stress differently, as some develop depressive symptoms …

A mediation meta‐analysis of the role of maternal responsivity in the association between socioeconomic risk and children's language

S Borairi, P Fearon, S Madigan… - Child …, 2021 - Wiley Online Library
This meta‐analysis tested maternal responsivity as a mediator of the association between
socioeconomic risk and children's preschool language abilities. The search included studies …

The efficacy and safety of some new gabakines for treatment of depression: a systematic review and meta-analysis from randomized controlled trials

J Zou, L Yang, G Yang, J Gao - Psychiatry Research, 2023 - Elsevier
Positive allosteric modulators of γ-aminobutyric acid-A (GABA A) receptors, or GABAkines,
play important roles in the treatment of depression, epilepsy, insomnia, and other disorders …

Tolerance-inducing effect and properties of innate immune stimulation on chronic stress-induced behavioral abnormalities in mice

Y Gu, T Ye, P Tan, L Tong, J Ji, Y Gu, Z Shen… - Brain, Behavior, and …, 2021 - Elsevier
Over-activation of the innate immune system constitutes a risk factor for the development of
nervous system disorders but may reduce the severity of these disorders by inducing …

μ-Opioid receptor (Oprm1) copy number influences nucleus accumbens microcircuitry and reciprocal social behaviors

C Toddes, EM Lefevre, DD Brandner… - Journal of …, 2021 - Soc Neuroscience
The μ-opioid receptor regulates reward derived from both drug use and natural experiences,
including social interaction, through actions in the nucleus accumbens. Here, we studied …

[HTML][HTML] Resilience to the effects of social stress on vulnerability to developing drug addiction

C Calpe-López, MA Martínez-Caballero… - World Journal of …, 2022 - ncbi.nlm.nih.gov
We review the still scarce but growing literature on resilience to the effects of social stress on
the rewarding properties of drugs of abuse. We define the concept of resilience and how it is …

Proper synaptic adhesion signaling in the control of neural circuit architecture and brain function

HY Kim, JW Um, J Ko - Progress in Neurobiology, 2021 - Elsevier
Trans-synaptic cell-adhesion molecules are critical for governing various stages of synapse
development and specifying neural circuit properties via the formation of multifarious …