Structural components of synaptic plasticity and memory consolidation

CH Bailey, ER Kandel… - Cold Spring Harbor …, 2015 - cshperspectives.cshlp.org
Consolidation of implicit memory in the invertebrate Aplysia and explicit memory in the
mammalian hippocampus are associated with remodeling and growth of preexisting …

Ultrastructure of synapses in the mammalian brain

KM Harris, RJ Weinberg - Cold Spring Harbor …, 2012 - cshperspectives.cshlp.org
The morphology and molecular composition of synapses provide the structural basis for
synaptic function. This article reviews the electron microscopy of excitatory synapses on …

Nanoconnectomic upper bound on the variability of synaptic plasticity

TM Bartol Jr, C Bromer, J Kinney, MA Chirillo… - elife, 2015 - elifesciences.org
Information in a computer is quantified by the number of bits that can be stored and
recovered. An important question about the brain is how much information can be stored at a …

Do thin spines learn to be mushroom spines that remember?

J Bourne, KM Harris - Current opinion in neurobiology, 2007 - Elsevier
Dendritic spines are the primary site of excitatory input on most principal neurons. Long-
lasting changes in synaptic activity are accompanied by alterations in spine shape, size and …

[HTML][HTML] Anterograde axonal transport in neuronal homeostasis and disease

L Guillaud, SE El-Agamy, M Otsuki… - Frontiers in molecular …, 2020 - frontiersin.org
Neurons are highly polarized cells with an elongated axon that extends far away from the
cell body. To maintain their homeostasis, neurons rely extensively on axonal transport of …

A cryo-ET survey of microtubules and intracellular compartments in mammalian axons

HE Foster, C Ventura Santos, AP Carter - Journal of Cell Biology, 2021 - rupress.org
The neuronal axon is packed with cytoskeletal filaments, membranes, and organelles, many
of which move between the cell body and axon tip. Here, we used cryo-electron tomography …

Distinct initial SNARE configurations underlying the diversity of exocytosis

H Kasai, N Takahashi, H Tokumaru - Physiological reviews, 2012 - journals.physiology.org
The dynamics of exocytosis are diverse and have been optimized for the functions of
synapses and a wide variety of cell types. For example, the kinetics of exocytosis varies by …

3D structural imaging of the brain with photons and electrons

M Helmstaedter, KL Briggman, W Denk - Current opinion in neurobiology, 2008 - Elsevier
Recent technological developments have renewed the interest in large-scale neural circuit
reconstruction. To resolve the structure of entire circuits, thousands of neurons must be …

Auditory brainstem circuits that mediate the middle ear muscle reflex

S Mukerji, AM Windsor, DJ Lee - Trends in amplification, 2010 - journals.sagepub.com
The middle ear muscle (MEM) reflex is one of two major descending systems to the auditory
periphery. There are two middle ear muscles (MEMs): the stapedius and the tensor tympani …

Evidence for Alzheimer's disease-linked synapse loss and compensation in mouse and human hippocampal CA1 pyramidal neurons

KM Neuman, E Molina-Campos, TF Musial… - Brain structure and …, 2015 - Springer
Alzheimer's disease (AD) is associated with alterations in the distribution, number, and size
of inputs to hippocampal neurons. Some of these changes are thought to be …