Functional hydrogels for the repair and regeneration of tissue defects

X Li, M Xu, Z Geng, Y Liu - Frontiers in Bioengineering and …, 2023 - frontiersin.org
Tissue defects can be accompanied by functional impairments that affect the health and
quality of life of patients. Hydrogels are three-dimensional (3D) hydrophilic polymer …

Mitigating cross-species viral infections in xenotransplantation: progress, strategies, and clinical outlook

Y Zhou, S Zhou, Q Wang, B Zhang - Cell Transplantation, 2024 - journals.sagepub.com
Xenotransplantation holds great promise as a solution to address the critical shortage of
organs, but it raises concerns regarding the potential transmission of porcine viruses to …

Co-expression of HLA-E and HLA-G on genetically modified porcine endothelial cells attenuates human NK cell-mediated degranulation

AA Cross-Najafi, K Farag, A Isidan, W Li… - Frontiers in …, 2023 - frontiersin.org
Natural killer (NK) cells play an important role in immune rejection in solid organ
transplantation. To mitigate human NK cell activation in xenotransplantation, introducing …

Current state of clinical trials on xenograft

J El Masri, A Afyouni, M Ghazi, T Baroud… - …, 2023 - Wiley Online Library
Background Xenotransplantation is a worth investing branch of science, since it aims to fulfil
the demand on human cells, tissues and organs. Despite decades of consistent work in …

Ethical and legislative advances in xenotransplantation for clinical translation: focusing on cardiac, kidney and islet cell xenotransplantation

WJ Hawthorne - Frontiers in immunology, 2024 - frontiersin.org
In this state-of-the-art review we detail the journey of xenotransplantation from its infancy,
detailing one of the first published cases and the subsequent journey the field took in its …

Chimeric Livers: Interspecies Blastocyst Complementation and Xenotransplantation for End-Stage Liver Disease

MJ Blake, CJ Steer - Hepatic Medicine: Evidence and Research, 2024 - Taylor & Francis
Orthotopic liver transplantation (OLT) currently serves as the sole definitive treatment for
thousands of patients suffering from end-stage liver disease; and the existing supply of …

Research prospects for kidney xenotransplantation: a bibliometric analysis

S Yang, M Zhang, H Wei, B Zhang, J Peng, P Shang… - Renal …, 2024 - Taylor & Francis
Background Xenograft kidney transplantation has been receiving increasing attention. The
purpose of this study is to use bibliometric analysis to identify papers in this research field …

Multiple gene modifications of pigs for overcoming obstacles of xenotransplantation

H Wu, M Lian, L Lai - National Science Open, 2023 - nso-journal.org
Xenotransplantation, involving animal organ transplantation into humans to address the
human organ shortage, has been studied since the 17th century. Early attempts to obtain …

In defense of xenotransplantation research: Because of, not in spite of, animal welfare concerns

C Bobier, D Rodger, DJ Hurst… - …, 2023 - Wiley Online Library
It is envisioned that one day xenotransplantation will bring about a future where
transplantable organs can be safely and efficiently grown in transgenic pigs to help meet the …

Xenotransplantation literature update March 2021–March 2023

S Kamberi, RPH Meier - 2023 - Wiley Online Library
After a significant hiatus imposed by the COVID‐19 pandemic, we hereby restart
Xenotransplantation literature updates. With the recently performed clinical …