Since the discovery of the RET receptor tyrosine kinase in 1985, alterations of this protein
have been found in diverse thyroid cancer subtypes. RET gene rearrangements are …

Hirschsprung disease (HSCR, aganglionic megacolon) represents the main genetic cause
of functional intestinal obstruction with an incidence of 1/5000 live births. This …

Hirschsprung disease (HSCR, aganglionic megacolon) is the main genetic cause of
functional intestinal obstruction with an incidence of 1/5000 live births. This developmental …

The variety of diseases caused by mutations in RET receptor tyrosine kinase provides a
classic example of phenotypic heterogeneity. Gain-of-function mutations of RET are …

The data reported in the past 5 years have highlighted new aspects of protein misfolding
and aggregation. Firstly, it appears that protein aggregation may be a generic property of …

Glial cell line-derived neurotrophic factor (GDNF) and related molecules, neurturin, artemin
and persephin, signal through a unique multicomponent receptor system consisting of RET …

The RET proto-oncogene encodes a receptor tyrosine kinase for the glial cell line-derived
neurotrophic factor family of ligands. Loss-of-function mutations in RET are implicated in …

Malignant tumors of the thyroid gland vary considerably in aggressiveness, ranging from a
well-differentiated, clinically indolent, to an undifferentiated, often lethal phenotype …

Mutations in receptor tyrosine kinases (RTKs) have been linked to an increasing number of
inherited human disease syndromes, including dwarfism, craniosynostosis, heritable cancer …

The RET proto-oncogene encodes a receptor tyrosine kinase whose alterations are
responsible for various human cancers and developmental disorders, including thyroid …