Cytotoxic chemotherapies have devastating side effects, particularly within the
gastrointestinal tract. Gastrointestinal toxicity includes the death and damage of the …

Efficient elimination of apoptotic cells within epithelial cell sheets is crucial for preserving
epithelial barrier integrity. 1 It is well established that immediate neighbors of an apoptotic …

Apical extrusion is a tissue-intrinsic process that allows epithelia to eliminate unfit or surplus
cells. This is exemplified by the early extrusion of apoptotic cells, which is critical to maintain …

Evasion of cell death is a hallmark of cancer, and consequently the induction of cell death is
a common strategy in cancer treatment. However, the molecular mechanisms regulating …

Apical extrusion is a tissue-intrinsic process that allows epithelia to eliminate unfit or surplus
cells. This is exemplified by the early extrusion of apoptotic cells, which is critical to maintain …

Caveolae are specialized plasma membrane domains with a unique lipid composition.
Recent work has implicated lipid peroxidation in triggering caveola disassembly, releasing …

The epithelial cell sheet maintains its integrity as a barrier while undergoing turnover of
constituent cells. To sustain the barrier continuously, it's essential to preserve the'old'tight …

Tissue development and cell behavior are influenced not only by chemical signals but also
by physical ones. The responses of cells to mechanical forces can range from the immediate …

Proinflammatory apoptosis | Science Signaling news careers commentary Journals Science
Science brought to you byGoogle Indexer Log in journal-menu-img science journal-menu-img …

1. 要旨上皮組織では細胞のターンオーバーが高頻度でおこっており, 絶えず細胞分裂により新たな
細胞が供給されると共に, 同等数の不要な細胞が除去されている. 上皮細胞が組織から除去される …