The therapeutic algorithm of renal cell carcinoma has been revolutionized by the approval of
immunotherapy agents by regulatory agencies. However, objective and durable responses …

Lipid droplet formation is a defining histological feature in clear-cell renal cell carcinoma
(ccRCC) but the underlying mechanisms and importance of this biological behaviour have …

Patients' metabolic and morphological status may impact their risk of developing different
types of tumors and the response to systemic therapy. However, further research is …

Purpose: High body mass index (BMI) may lead to improved immune-checkpoint blockade
(ICB) outcomes in metastatic clear cell renal cell carcinoma (mccRCC). However, BMI is a …

Obesity, defined by body mass index (BMI), is an established risk factor for specific renal cell
carcinoma (RCC) subtypes such as clear cell RCC, the most common RCC histology. Many …

Abstract Purpose: Overweight/obese (OW/OB) patients with metastatic melanoma
unexpectedly have improved outcomes with immune checkpoint inhibitors (ICI) and BRAF …

Background Immune checkpoint inhibitors (ICI) have revolutionized the treatment of
metastatic renal cell carcinoma (mRCC). Biomarkers for mRCC patients treated with ICI are …

Background Imbalanced body composition is mechanistically connected to dysregulated
immune activities. Whether overweight/obesity or sarcopenia has an impact on treatment …

Context Body mass index (BMI) is a useful tool for measuring body composition. It is unclear
whether high BMI is a favourable indicator in patients with metastatic renal cell carcinoma …

BACKGROUND. Obesity is the foremost risk factor in the development of endometrial cancer
(EC). However, the impact of obesity on the response to immune checkpoint inhibitors (ICI) …