Simple Summary The tumor microenvironment (TME) in breast cancer plays important roles
in tumor behavior and treatment response, making its pathologic assessment critical for …

Cancer stem cells (CSC) are a distinct subpopulation within a tumor. They are able to self-
renew and differentiate and possess a high capability to repair DNA damage, exhibit low …

The stroma in solid tumors contains a variety of cellular phenotypes and signaling pathways
associated with wound healing, leading to the concept that a tumor behaves as a wound that …

Fibroblasts have exceptional phenotypic plasticity and capability to secrete vast amount of
soluble factors, extracellular matrix components and extracellular vesicles. While in …

Simple Summary Chronic inflammation is an important cause of multiple cancers. While
chronic inflammation is present in breast cancer and may influence its outcome, its role in …

Environment-mediated drug resistance is a form of de novo drug resistance that protects
tumour cells from the initial effects of diverse therapies. Surviving foci of residual disease …

Since the first prospective identification of cancer stem cells in solid cancers the cancer stem
cell hypothesis has reemerged as a research topic of increasing interest. It postulates that …

Pancreatic tumors are known to harbor an abundant and highly desmoplastic stroma.
Among the various cell types that reside within tumor stroma, cancer-associated fibroblasts …

Simple Summary Cancer is multifaceted and consists of more than just a collection of
mutated cells. These cancerous cells reside along with other non-mutated cells in an …

Ovarian cancer has a unique tumor microenvironment (TME) that enables cancer-
associated fibroblasts (CAFs) to interact with cellular and matrix constituents and influence …