Neuroinflammation and depression: microglia activation, extracellular microvesicles and microRNA dysregulation

D Brites, A Fernandes - Frontiers in cellular neuroscience, 2015 - frontiersin.org
Patients with chronic inflammation are often associated with the emergence of depression
symptoms, while diagnosed depressed patients show increased levels of circulating …

Stress-induced perinatal and transgenerational epigenetic programming of brain development and mental health

O Babenko, I Kovalchuk, GAS Metz - Neuroscience & Biobehavioral …, 2015 - Elsevier
Research efforts during the past decades have provided intriguing evidence suggesting that
stressful experiences during pregnancy exert long-term consequences on the future mental …

Schizophrenia is defined by cell-specific neuropathology and multiple neurodevelopmental mechanisms in patient-derived cerebral organoids

M Notaras, A Lodhi, F Dündar, P Collier… - Molecular …, 2022 - nature.com
Due to an inability to ethically access developing human brain tissue as well as identify
prospective cases, early-arising neurodevelopmental and cell-specific signatures of …

Exosomes provide a protective and enriched source of miRNA for biomarker profiling compared to intracellular and cell-free blood

L Cheng, RA Sharples, BJ Scicluna… - Journal of extracellular …, 2014 - Taylor & Francis
Introduction microRNA (miRNA) are small non-coding RNA species that are transcriptionally
processed in the host cell and released extracellularly into the bloodstream. Normally …

The role of microRNAs in the pathophysiology of human central nervous system: a focus on neurodegenerative diseases

D Rezaee, F Saadatpour, N Akbari, A Zoghi… - Ageing Research …, 2023 - Elsevier
Abstract microRNAs (miRNAs) are suggested to play substantial roles in regulating the
development and various physiologic functions of the central nervous system (CNS). These …

Microglia secrete miR-146a-5p-containing exosomes to regulate neurogenesis in depression

C Fan, Y Li, T Lan, W Wang, Y Long, SY Yu - Molecular Therapy, 2022 - cell.com
Enhancing neurogenesis within the hippocampal dentate gyrus (DG) is critical for
maintaining brain development and function in many neurological diseases. However, the …

MicroRNAs in development and disease

D Sayed, M Abdellatif - Physiological reviews, 2011 - journals.physiology.org
MicroRNAs (miRNAs) are a class of posttranscriptional regulators that have recently
introduced an additional level of intricacy to our understanding of gene regulation. There are …

An unconventional role for miRNA: let-7 activates Toll-like receptor 7 and causes neurodegeneration

SM Lehmann, C Krüger, B Park, K Derkow… - Nature …, 2012 - nature.com
Activation of innate immune receptors by host-derived factors exacerbates CNS damage, but
the identity of these factors remains elusive. We uncovered an unconventional role for the …

Oncomirs—microRNAs with a role in cancer

A Esquela-Kerscher, FJ Slack - Nature reviews cancer, 2006 - nature.com
MicroRNAs (miRNAs) are an abundant class of small non-protein-coding RNAs that function
as negative gene regulators. They regulate diverse biological processes, and bioinformatic …

[HTML][HTML] The role of microRNAs in human diseases

AM Ardekani, MM Naeini - Avicenna journal of medical …, 2010 - ncbi.nlm.nih.gov
MicroRNAs (miRNAs) are short RNA molecules which bind to target mRNAs, resulting in
translational repression and gene silencing and are found in all eukaryotic cells …