Patients suffering from iron overload can experience serious complications. In such patients,
various organs, such as endocrine glands and liver, can be damaged. Although iron is a …

Sickle cell disease (SCD) is a genetic disease caused by a single mutation in the β-globin
gene, leading to the production of an abnormal hemoglobin called hemoglobin S (HbS) …

The primary role of red blood cells (RBCs) is to transport oxygen to the tissues and carbon
dioxide to the lungs. However, emerging evidence suggests an important role of the RBC …

Sickle cell disease (SCD) is the most common hereditary disorder of hemoglobin (Hb),
which affects approximately a million people worldwide. It is characterized by a single …

Hemolytic diseases are associated with elevated levels of circulating free heme that can
mediate endothelial dysfunction directly via redox reactions with biomolecules or indirectly …

Diseases impacting the production, longevity, and function of the hemoglobin molecule are
diverse in their impact on an individual and population basis. This article focuses on sickle …

Sickle cell disease (SCD) is an inherited monogenic disorder and the most common severe
hemoglobinopathy in the world. SCD is characterized by a point mutation in the β-globin …

Vascular endothelial cells line the inner surface of the entire cardiovascular system as a
single layer and are involved in an impressive array of functions, ranging from the regulation …

Sickle cell disease (SCD) is a monogenic inheritable disease characterized by severe
anemia, increased hemolysis, and recurrent, painful vaso-occlusive crises due to the …

Background: The phenotypic expression of sickle cell disease (SCD) is a complex
pathophysiologic condition. However, sickle erythrocytes might be the cause for multiple …