Ras proteins play a crucial role as a central component of the cellular networks controlling a
variety of signaling pathways that regulate growth, proliferation, survival, differentiation …

Pancreatic ductal adenocarcinoma (PDAC) is the most common type of pancreatic cancer. It
has a poor response to conventional therapy and has an extremely poor 5-year survival rate …

Pancreatic ductal adenocarcinoma (PDAC) is a devastating disease. Circulating tumor cells
(CTC) in the blood are hypothesized as the means of systemic tumor spread. Blood obtained …

Importance Ampullary adenocarcinoma is a rare malignant neoplasm that arises within the
duodenal ampullary complex. The role of adjuvant therapy (AT) in the treatment of ampullary …

Abstract The KRAS/K-RAS oncogene is crucially involved in human cancer. The term
“oncogene”–ie, a gene able to transform a normal cell into a tumor cell–was introduced in …

Periampullary cancers include pancreatic, ampullary, biliary and duodenal cancers. At
presentation, the majority of periampullary tumours have grown to involve the pancreas, bile …

Histologically, ampullary carcinomas (ACs) can be classified into intestinal (INT-AC) and
pancreatobiliary (PB-AC) subtypes. However, the prognostic implications of these subtypes …

Kirsten rat sarcoma (KRAS) is one of the most frequently mutated oncogenes in solid
tumours. It encodes an important signalling pathway that drives cellular proliferation and …

Objective: To identify molecular prognostic factors and potentially actionable mutations in
ampulla of Vater cancer (AVC). Background: The largely variable outcomes of AVCs make …

Pancreatic ductal adenocarcinoma (PDAC) is most often diagnosed in a metastatic stage.
Circulating tumor cells (CTC) in the blood are hypothesized as the means of systemic …