Life is characterized by a myriad of complex dynamic processes allowing organisms to grow,
reproduce, and evolve. Physical approaches for describing systems out of thermodynamic …

Acetyl-CoA is a metabolite at the crossroads of central metabolism and the substrate of
histone acetyltransferases regulating gene expression. In many tissues fasting or lifespan …

Aging of organisms begins from a single cell at the molecular level. It includes changes
related to telomere shortening, cell senescence and epigenetic modifications. These …

Aging cells accumulate damaged and misfolded proteins through a functional decline in
their protein homeostasis (proteostasis) machinery, leading to reduced cellular viability and …

Since the first publication on Somatic Mutation Theory of Aging (Szilárd, 1959), a great
volume of knowledge in the field has been accumulated. Here we attempted to organize the …

Carbon dioxide capture and storage (CCS) technology is considered by many to be an
essential route to meet climate mitigation targets in the power and industrial sectors …

One of the original hypotheses of organismal longevity posits that aging is the natural result
of entropy on the cells, tissues, and organs of the animal—a slow, inexorable slide into …

Ageing is marked by physical decline. Caenorhabditis elegans is a valuable model for
identifying genetic regulatory mechanisms of ageing and longevity. Here we report a simple …

Genetic conservation allows ancient features of fat storage endocrine pathways to be
explored in C. elegans. Multiple studies have used Nile red or BODIPY-labeled fatty acids to …

Fat is stored or mobilized according to food availability. Malfunction of the mechanisms that
ensure this coordination underlie metabolic diseases in humans. In mammals, lysosomal …