The availability of the human genome sequence has revolutionized the strategy of
employing nucleic acids with sequences complementary to specific target genes to improve …

RNA interference (RNAi) is now an umbrella term referring to post-transcriptional gene
silencing mediated by either degradation or translation arrest of target RNA. This process is …

RNA interference (RNAi) represents a powerful, naturally occurring biological strategy for
inhibition of gene expression. It is mediated through small interfering RNAs (siRNAs), which …

Vascular remodeling in host tissues surrounding growing tumors is implicated in the
successful development of tumor neovasculature. Cooperation between vascular …

An RNA hairpin is an essential secondary structure of RNA. It can guide RNA folding,
determine interactions in a ribozyme, protect messenger RNA (mRNA) from degradation …

Cancer is the second leading cause of death in the western world. Despite advances in
diagnosis and treatment, overall survival of patients remains poor. Scientific advances in …

Vascular normalization is a new concept of targeting angiogenesis to restore vessel
structure and function and to increase blood perfusion and delivery of drugs. It has been …

Vascular endothelial growth factor (VEGF) and its receptors have been implicated as key
factors in tumor angiogenesis that are up-regulated by hypoxia. We evaluated the effects of …

Vascular endothelial growth factor (VEGF) has proven to be the most critical angiogenic
factor identified to date; its discovery has transformed the field of angiogenesis research …

The ability of small-interfering RNAs (siRNAs) to silence gene expression in somatic
mammalian cells has provided researchers with a novel tool to block the expression of …