Sex-related responses after traumatic brain injury: Considerations for preclinical modeling

CB Späni, DJ Braun, LJ Van Eldik - Frontiers in neuroendocrinology, 2018 - Elsevier
Traumatic brain injury (TBI) has historically been viewed as a primarily male problem, since
men are more likely to experience a TBI because of more frequent participation in activities …

Neuro-inflammation modulation and post-traumatic brain injury lesions: from bench to bed-side

A Jacquens, EJ Needham, ER Zanier, V Degos… - International journal of …, 2022 - mdpi.com
Head trauma is the most common cause of disability in young adults. Known as a silent
epidemic, it can cause a mosaic of symptoms, whether neurological (sensory–motor …

Combination therapies for neurobehavioral and cognitive recovery after experimental traumatic brain injury: is more better?

AE Kline, JB Leary, HL Radabaugh, JP Cheng… - Progress in …, 2016 - Elsevier
Traumatic brain injury (TBI) is a significant health care crisis that affects two million
individuals in the United Sates alone and over ten million worldwide each year. While …

Multi-mechanistic approaches to the treatment of traumatic brain injury: A review

DG Lynch, RK Narayan, C Li - Journal of Clinical Medicine, 2023 - mdpi.com
Traumatic brain injury (TBI) is a leading cause of death and disability worldwide. Despite
extensive research efforts, the majority of trialed monotherapies to date have failed to …

[HTML][HTML] Prophylactic progesterone prevents adverse behavioural and neurocognitive effects of neonatal anaesthesia exposure in rat

B Wali, I Sayeed, DG Stein, J Raper - British Journal of Anaesthesia, 2022 - Elsevier
Background Evidence from animal models and human studies suggests an association
between early general anaesthesia exposure and development of long-lasting …

Glucocorticoid receptor overexpression in the dorsal hippocampus attenuates spatial learning and synaptic plasticity deficits after pediatric traumatic brain injury

D Lengel, ZL Romm, A Bostwick, JW Huh… - Journal of …, 2022 - liebertpub.com
Traumatic brain injury (TBI) in children< 4 years of age leads to long-term deficits in
cognitive and learning abilities that can persist or even worsen as these children age into …

Progesterone protects mitochondrial function in a rat model of pediatric traumatic brain injury

CL Robertson, M Saraswati - Journal of bioenergetics and biomembranes, 2015 - Springer
Progesterone has been studied extensively in preclinical models of adult traumatic brain
injury (TBI), and has advanced to clinical trials in adults with TBI. However, there are very …

Progesterone treatment following traumatic brain injury in the 11-day-old rat attenuates cognitive deficits and neuronal hyperexcitability in adolescence

D Lengel, JW Huh, JR Barson, R Raghupathi - Experimental neurology, 2020 - Elsevier
Traumatic brain injury (TBI) in children younger than 4 years old results in cognitive and
psychosocial deficits in adolescence and adulthood. At 4 weeks following closed head injury …

Progesterone treatment shows benefit in a pediatric model of moderate to severe bilateral brain injury

RI Geddes, EA Sribnick, I Sayeed, DG Stein - PLoS One, 2014 - journals.plos.org
Purpose Controlled cortical impact (CCI) models in adult and aged Sprague-Dawley (SD)
rats have been used extensively to study medial prefrontal cortex (mPFC) injury and the …

[HTML][HTML] Improved spatial memory, neurobehavioral outcomes, and neuroprotective effect after progesterone administration in ovariectomized rats with traumatic brain …

L Amirkhosravi, M Khaksari, V Sheibani… - Iranian Journal of …, 2021 - ncbi.nlm.nih.gov
Objective (s): The contribution of classic progesterone receptors (PR) in interceding the
neuroprotective efficacy of progesterone (P4) on the prevention of brain edema and long …