Sex-related responses after traumatic brain injury: Considerations for preclinical modeling
Traumatic brain injury (TBI) has historically been viewed as a primarily male problem, since
men are more likely to experience a TBI because of more frequent participation in activities …
men are more likely to experience a TBI because of more frequent participation in activities …
Neuro-inflammation modulation and post-traumatic brain injury lesions: from bench to bed-side
Head trauma is the most common cause of disability in young adults. Known as a silent
epidemic, it can cause a mosaic of symptoms, whether neurological (sensory–motor …
epidemic, it can cause a mosaic of symptoms, whether neurological (sensory–motor …
Combination therapies for neurobehavioral and cognitive recovery after experimental traumatic brain injury: is more better?
AE Kline, JB Leary, HL Radabaugh, JP Cheng… - Progress in …, 2016 - Elsevier
Traumatic brain injury (TBI) is a significant health care crisis that affects two million
individuals in the United Sates alone and over ten million worldwide each year. While …
individuals in the United Sates alone and over ten million worldwide each year. While …
Multi-mechanistic approaches to the treatment of traumatic brain injury: A review
DG Lynch, RK Narayan, C Li - Journal of Clinical Medicine, 2023 - mdpi.com
Traumatic brain injury (TBI) is a leading cause of death and disability worldwide. Despite
extensive research efforts, the majority of trialed monotherapies to date have failed to …
extensive research efforts, the majority of trialed monotherapies to date have failed to …
[HTML][HTML] Prophylactic progesterone prevents adverse behavioural and neurocognitive effects of neonatal anaesthesia exposure in rat
B Wali, I Sayeed, DG Stein, J Raper - British Journal of Anaesthesia, 2022 - Elsevier
Background Evidence from animal models and human studies suggests an association
between early general anaesthesia exposure and development of long-lasting …
between early general anaesthesia exposure and development of long-lasting …
Glucocorticoid receptor overexpression in the dorsal hippocampus attenuates spatial learning and synaptic plasticity deficits after pediatric traumatic brain injury
D Lengel, ZL Romm, A Bostwick, JW Huh… - Journal of …, 2022 - liebertpub.com
Traumatic brain injury (TBI) in children< 4 years of age leads to long-term deficits in
cognitive and learning abilities that can persist or even worsen as these children age into …
cognitive and learning abilities that can persist or even worsen as these children age into …
Progesterone protects mitochondrial function in a rat model of pediatric traumatic brain injury
CL Robertson, M Saraswati - Journal of bioenergetics and biomembranes, 2015 - Springer
Progesterone has been studied extensively in preclinical models of adult traumatic brain
injury (TBI), and has advanced to clinical trials in adults with TBI. However, there are very …
injury (TBI), and has advanced to clinical trials in adults with TBI. However, there are very …
Progesterone treatment following traumatic brain injury in the 11-day-old rat attenuates cognitive deficits and neuronal hyperexcitability in adolescence
D Lengel, JW Huh, JR Barson, R Raghupathi - Experimental neurology, 2020 - Elsevier
Traumatic brain injury (TBI) in children younger than 4 years old results in cognitive and
psychosocial deficits in adolescence and adulthood. At 4 weeks following closed head injury …
psychosocial deficits in adolescence and adulthood. At 4 weeks following closed head injury …
Progesterone treatment shows benefit in a pediatric model of moderate to severe bilateral brain injury
RI Geddes, EA Sribnick, I Sayeed, DG Stein - PLoS One, 2014 - journals.plos.org
Purpose Controlled cortical impact (CCI) models in adult and aged Sprague-Dawley (SD)
rats have been used extensively to study medial prefrontal cortex (mPFC) injury and the …
rats have been used extensively to study medial prefrontal cortex (mPFC) injury and the …
[HTML][HTML] Improved spatial memory, neurobehavioral outcomes, and neuroprotective effect after progesterone administration in ovariectomized rats with traumatic brain …
Objective (s): The contribution of classic progesterone receptors (PR) in interceding the
neuroprotective efficacy of progesterone (P4) on the prevention of brain edema and long …
neuroprotective efficacy of progesterone (P4) on the prevention of brain edema and long …