Tumor breaching the capsule of a lymph node is termed extranodal extension (ENE). It
reflects aggressiveness of a tumor, creates anatomic challenges for disease clearance, and …

Detection of extranodal extension on histopathology in surgically treated head and neck
squamous cell carcinoma indicates poor prognosis. However, there is no consensus on the …

Objectives To investigate the potential of dual-energy computed tomography (DECT)
parameters in identifying metastatic cervical lymph nodes in oral squamous cell carcinoma …

Abstract Background Both microRNA-21-5p (miR-21) and the tumor microenvironment,
including hypoxia and cancer-associated fibroblasts (CAFs), play a vital role in head and …

Arecoline, the main alkaloid of areca nut, is well known for its role in inducing submucosal
fibrosis and oral squamous cell carcinoma (OSCC), however the mechanism remains …

Objective Oral squamous cell carcinoma (OSCC) is the most frequent oral malignancy with a
poor prognosis, in which tumor-infiltrating immune cells may play a critical role. Therefore …

Background In oral squamous cell carcinoma (OSCC), the tumor-node-metastasis (TNM)
staging system is a significant factor that influences prognosis and treatment decisions for …

Oral squamous cell carcinoma (OSCC) is one of the most common cancers worldwide, and
with 354 864 new cases each year. Cancer metastasis, recurrence, and drug resistance are …

Background Perineural invasion (PNI) is recognized as a poor prognostic factor in oral
squamous cell carcinoma (OSCC). However, the prognostic significance of further histologic …

Simple Summary Lymph node ratio (LNR) is a well-studied prognostic factor in colorectal
and breast cancer, and it has been recently evaluated as a clinically relevant biomarker in …