Recent developments in bioprocessing of recombinant proteins: expression hosts and process development

NK Tripathi, A Shrivastava - Frontiers in Bioengineering and …, 2019 - frontiersin.org
Infectious diseases, along with cancers, are among the main causes of death among
humans worldwide. The production of therapeutic proteins for treating diseases at large …

Progress in biopharmaceutical development

M Kesik‐Brodacka - Biotechnology and applied biochemistry, 2018 - Wiley Online Library
Since its introduction in 1982, biopharmaceutical drugs have revolutionized the treatment of
a broad spectrum of diseases and are increasingly used in nearly all branches of medicine …

Expression systems and species used for transgenic animal bioreactors

Y Wang, S Zhao, L Bai, J Fan… - BioMed Research …, 2013 - Wiley Online Library
Transgenic animal bioreactors can produce therapeutic proteins with high value for
pharmaceutical use. In this paper, we compared different systems capable of producing …

MiR-103 Controls Milk Fat Accumulation in Goat (Capra hircus) Mammary Gland during Lactation

X Lin, J Luo, L Zhang, W Wang, D Gou - PLoS One, 2013 - journals.plos.org
Milk is the primary source of nutrition for young mammals including humans. The nutritional
value of milk is mainly attributable to fats and proteins fractions. In comparison to cow milk …

In vitro production of small ruminant embryos: late improvements and further research

JMG de Souza-Fabjan, B Panneau, N Duffard… - Theriogenology, 2014 - Elsevier
Beyond the potential use of in vitro production of embryos (IVP) in breeding schemes,
embryos are also required for the establishment of new biotechnologies such as cloning and …

Genetically modified animals from life-science, socio-economic and ethical perspectives: Examining issues in an EU policy context

LJ Frewer, GA Kleter, M Brennan, D Coles… - New biotechnology, 2013 - Elsevier
The interdisciplinary EC consortium (the PEGASUS project) aimed to examine the issues
raised by the development, implementation and commercialisation of genetically modified …

[PDF][PDF] Genetic modification of animals: Scientific and ethical issues

J Bailey - Animal Experimentation: Working Towards a Paradigm …, 2019 - library.oapen.org
The scientific method demands a willingness to correct and integrate previous knowledge,
based on observable, empirical, measurable evidence and subject to laws of reasoning; yet …

Genetically Engineered Goats as Efficient Mammary Gland Bioreactors for Production of Recombinant Human Neutrophil Peptide 1 Using CRISPR/Cas9

D Li, R Guo, F Chen, J Wang, F Wang, Y Wan - Biology, 2024 - mdpi.com
Mammary gland bioreactors are promising methods for recombinant protein production.
Human neutrophil peptide 1 (HNP1) exhibits antibacterial and immune-modulating …

Therapeutic proteins: developments, progress, challenges, and future perspectives

V Kumar, A Barwal, N Sharma, DS Mir, P Kumar… - 3 Biotech, 2024 - Springer
Proteins are considered magic molecules due to their enormous applications in the health
sector. Over the past few decades, therapeutic proteins have emerged as a promising …

Site-Specific N-Glycosylation of Caprine Lysostaphin Restricts its Bacteriolytic Activity Toward Staphylococcus Aureus

CY Huang, JT Hsu, PH Chung, WTK Cheng… - Animal …, 2013 - Taylor & Francis
Lysostaphin (LYS) is an anti-staphylococcal prokaryotic polypeptide that has been used to
avoid Staphylococcus aureus mastitis through transgenic or viral vector approaches …