In diabetes mellitus, the polyol pathway is highly active and consumes approximately 30%
glucose in the body. This pathway contains 2 reactions catalyzed by aldose reductase (AR) …

Neuropathy is the most common and debilitating complication of diabetes and results in
pain, decreased motility, and amputation. Diabetic neuropathy encompasses a variety of …

Aldose reductase (AR) is an aldo-keto reductase that catalyzes the first step in the polyol
pathway which converts glucose to sorbitol. Under normal glucose homeostasis the pathway …

Cells in the renal inner medulla are normally exposed to extraordinarily high levels of NaCl
and urea. The osmotic stress causes numerous perturbations because of the hypertonic …

The polyol pathway is a two-step metabolic pathway in which glucose is reduced to sorbitol,
which is then converted to fructose. It is one of the most attractive candidate mechanisms to …

Diabetes mellitus occurrence has been associated to the modification of the physiological
levels of glucose and is often accompanied by several long-term complications, namely …

A series of novel sulfonates containing quinazolin‐4 (3 H)‐one ring derivatives was
designed to inhibit aldose reductase (ALR2, EC 1.1. 1.21). Novel quinazolinone derivatives …

NAD+ is a fundamental molecule in metabolism and redox signaling. In diabetes and its
complications, the balance between NADH and NAD+ can be severely perturbed. On one …

Covering: up to May 2010 This review (with 335 references cited) is devoted to pentacyclic
triterpenes. The total synthesis, semi-synthesis, structural modification, and metabolic …

In our work, it was purposed to investigate the effects of sodium arsenite (SA) and hesperidin
(HSP) administered to rats on some metabolic enzymes including carbonic anhydrase (CA) …