The advent of genome editing has transformed the therapeutic landscape for several
debilitating diseases, and the clinical outlook for gene therapeutics has never been more …

The targeted and efficiency-oriented delivery of (therapeutic) nucleic acids raises hope for
successful gene therapy, ie, for the local and individual treatment of acquired and inherited …

Zwitterionic polymers are generally viewed as a new class of nonfouling materials. Unlike
their poly (ethylene glycol)(PEG) counterparts, zwitterionic polymers have a broader …

1. DENDRIMERS AND GENE DELIVERY Gene therapy represents a promising option for
the treatment of diseases such as inherited disorders, viral infections, and cancers. 1− 3 A …

Polymers have shown great promise in the design of high efficient and low cytotoxic gene
vectors. Here we synthesize fluorinated dendrimers for use as gene vectors. Fluorinated …

Functional siRNAs are employed as cross‐linkers to direct the self‐assembly of DNA‐
grafted polycaprolactone (DNA‐g‐PCL) brushes to form spherical and nanosized hydrogels …

Drug resistance of pathogenic bacteria is a major global problem leading humanity towards
a pre-antibiotic era. Decline in the discovery of novel antibiotics and the lack of a resilient …

Substrate-initiated, self-inactivating, cell-penetrating poly (disulfide) s (siCPDs) are
introduced as general transporters for the covalent delivery of unmodified substrates of free …

An ideal vector in gene therapy should exhibit high serum stability, excellent
biocompatibility, a desired transfection efficacy and permeability into targeted tissues. Here …

Cationic poly (amidoamine)(PAMAM) dendrimers were widely used as nonviral gene
carriers. PAMAM dendrimer-based products such as Superfect and Priofect were already …