Pentamidine sensitizes Gram-negative pathogens to antibiotics and overcomes acquired colistin resistance
The increasing use of polymyxins 1 in addition to the dissemination of plasmid-borne colistin
resistance threatens to cause a serious breach in our last line of defence against multidrug …
resistance threatens to cause a serious breach in our last line of defence against multidrug …
Inhibiting fatty acid synthesis overcomes colistin resistance
Treating multidrug-resistant infections has increasingly relied on last-resort antibiotics,
including polymyxins, for example colistin. As polymyxins are given routinely, the prevalence …
including polymyxins, for example colistin. As polymyxins are given routinely, the prevalence …
Systems-level chemical biology to accelerate antibiotic drug discovery
Conspectus Drug-resistant bacterial infections pose an imminent and growing threat to
public health. The discovery and development of new antibiotics of novel chemical class and …
public health. The discovery and development of new antibiotics of novel chemical class and …
Outer membrane disruption overcomes intrinsic, acquired, and spontaneous antibiotic resistance
CR MacNair, ED Brown - MBio, 2020 - Am Soc Microbiol
Disruption of the outer membrane (OM) barrier allows for the entry of otherwise inactive
antimicrobials into Gram-negative pathogens. Numerous efforts to implement this approach …
antimicrobials into Gram-negative pathogens. Numerous efforts to implement this approach …
A common platform for antibiotic dereplication and adjuvant discovery
Solving the antibiotic resistance crisis requires the discovery of new antimicrobial drugs and
the preservation of existing ones. The discovery of inhibitors of antibiotic resistance …
the preservation of existing ones. The discovery of inhibitors of antibiotic resistance …
Bicarbonate alters bacterial susceptibility to antibiotics by targeting the proton motive force
The antibacterial properties of sodium bicarbonate have been known for years, yet the
molecular understanding of its mechanism of action is still lacking. Utilizing chemical …
molecular understanding of its mechanism of action is still lacking. Utilizing chemical …
Cold stress makes Escherichia coli susceptible to glycopeptide antibiotics by altering outer membrane integrity
A poor understanding of the mechanisms by which antibiotics traverse the outer membrane
remains a considerable obstacle to the development of novel Gram-negative antibiotics …
remains a considerable obstacle to the development of novel Gram-negative antibiotics …
A macrophage-based screen identifies antibacterial compounds selective for intracellular Salmonella Typhimurium
Abstract Salmonella Typhimurium (S. Tm) establishes systemic infection in susceptible hosts
by evading the innate immune response and replicating within host phagocytes. Here, we …
by evading the innate immune response and replicating within host phagocytes. Here, we …
Gene dispensability in Escherichia coli grown in thirty different carbon environments
Central metabolism is a topic that has been studied for decades, and yet, this process is still
not fully understood in Escherichia coli, perhaps the most amenable and well-studied model …
not fully understood in Escherichia coli, perhaps the most amenable and well-studied model …
A robust platform for chemical genomics in bacterial systems
While genetic perturbation has been the conventional route to probing bacterial systems,
small molecules are showing great promise as probes for cellular complexity. Indeed …
small molecules are showing great promise as probes for cellular complexity. Indeed …