piggyBac-ing models and new therapeutic strategies
LE Woodard, MH Wilson - Trends in biotechnology, 2015 - cell.com
DNA transposons offer an efficient nonviral method of permanently modifying the genomes
of mammalian cells. The piggyBac transposon system has proven effective in genomic …
of mammalian cells. The piggyBac transposon system has proven effective in genomic …
[HTML][HTML] Human iPSC-derived natural killer cells engineered with chimeric antigen receptors enhance anti-tumor activity
Chimeric antigen receptors (CARs) significantly enhance the anti-tumor activity of immune
effector cells. Although most studies have evaluated CAR expression in T cells, here we …
effector cells. Although most studies have evaluated CAR expression in T cells, here we …
[HTML][HTML] Development of innate immune cells from human pluripotent stem cells
Mouse and human pluripotent stem cells have been widely used to study the development
of the hematopoietic and immune systems. Although not all cells can be derived with the …
of the hematopoietic and immune systems. Although not all cells can be derived with the …
Rapid lentiviral vector producer cell line generation using a single DNA construct
YH Chen, C Pallant, CJ Sampson, A Boiti… - … Therapy Methods & …, 2020 - cell.com
Stable suspension producer cell lines for the production of vesicular stomatitis virus
envelope glycoprotein (VSVg)-pseudotyped lentiviral vectors represent an attractive …
envelope glycoprotein (VSVg)-pseudotyped lentiviral vectors represent an attractive …
Highly multiplexed genome engineering using CRISPR/Cas9 gRNA arrays
The CRISPR/Cas9 system is an RNA guided nuclease system that evolved as a mechanism
of adaptive immunity in bacteria. This system has been adopted for numerous genome …
of adaptive immunity in bacteria. This system has been adopted for numerous genome …
Concise review: human pluripotent stem cells to produce cell-based cancer immunotherapy
Human pluripotent stem cells (PSCs) provide a promising resource to produce immune cells
for adoptive cellular immunotherapy to better treat and potentially cure otherwise lethal …
for adoptive cellular immunotherapy to better treat and potentially cure otherwise lethal …
Modified cells and methods of therapy
B Moriarity, B Webber, M Choudhry, RS McIvor… - US Patent …, 2021 - Google Patents
US11147837B2 - Modified cells and methods of therapy - Google Patents US11147837B2 -
Modified cells and methods of therapy - Google Patents Modified cells and methods of therapy …
Modified cells and methods of therapy - Google Patents Modified cells and methods of therapy …
Simple and efficient methods for enrichment and isolation of endonuclease modified cells
BS Moriarity, EP Rahrmann, DA Beckmann… - PloS one, 2014 - journals.plos.org
The advent of Transcription Activator-Like Effector Nucleases (TALENs), and similar
technologies such as CRISPR, provide a straightforward and cost effective option for …
technologies such as CRISPR, provide a straightforward and cost effective option for …
Using RNA-seq and targeted nucleases to identify mechanisms of drug resistance in acute myeloid leukemia
SK Rathe, BS Moriarity, CB Stoltenberg, M Kurata… - Scientific reports, 2014 - nature.com
The evolution from microarrays to transcriptome deep-sequencing (RNA-seq) and from RNA
interference to gene knockouts using Clustered Regularly Interspaced Short Palindromic …
interference to gene knockouts using Clustered Regularly Interspaced Short Palindromic …
Intracellular genomic transplant and methods of therapy
B Moriarity, B Webber, M Choudhry… - US Patent …, 2024 - Google Patents
2018-11-08 Assigned to THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE
SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES reassignment THE …
SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES reassignment THE …