The day of extubation is a critical time during an intensive care unit (ICU) stay. Extubation is
usually decided after a weaning readiness test involving spontaneous breathing on a T …

Current research is focusing on preventing extubation failure, especially in the most
challenging cases. The use of weaning protocols–written or computerized–attempts to early …

Background Current management practices and outcomes in weaning from invasive
mechanical ventilation are poorly understood. We aimed to describe the epidemiology …

Background Spontaneous-breathing trials can be performed with the use of either pressure-
support ventilation (PSV) or a T-piece. Whether PSV trials may result in a shorter time to …

Importance Studies of mechanically ventilated critically ill patients that combine populations
that are at high and low risk for reintubation suggest that conditioned high-flow nasal …

Rationale: Diaphragm atrophy and dysfunction have been reported in humans during
mechanical ventilation, but the prevalence, causes, and functional impact of changes in …

Rationale: The weaning process concerns all patients receiving mechanical ventilation. A
previous classification into simple, prolonged, and difficult weaning ignored weaning failure …

Importance Daily spontaneous breathing trials (SBTs) are the best approach to determine
whether patients are ready for disconnection from mechanical ventilation, but mode and …

Objective: Postextubation distress after a successful spontaneous breathing trial is
associated with increased morbidity and mortality. Predicting postextubation distress is …

Objective: The influence of delirium, ICU-acquired paresis, and cardiac performance on
extubation outcome has never been evaluated together. We aimed to assess the respective …