This perspective aims at celebrating the 100th anniversary of the discovery of the Passerini
three component reaction. After being nearly neglected for many years, now this reaction …

This review covers the recent developments (since 2015) of enantioselective
desymmetrization reactions using metal-catalyzed, organocatalyzed and enzymatic …

Passerini three-component reactions (P-3CRs) based on isonitriles are impressive synthetic
protocols in which a number of starting materials react with each other to provide poly …

A concise and modular total synthesis of the highly potent N14-desacetoxytubulysin H (1)
has been accomplished in 18 steps in an overall yield of up to 30%. Our work highlights the …

The enantioselective control of the three-component Passerini reaction was successfully
achieved using chiral phosphoric acid as a catalyst with a wide range of substrates and high …

In this review the recent reports of biocatalytic reactions applied to the desymmetrization of
meso-compounds or symmetric prochiral molecules are summarized. The survey of …

The synthesis of ester-containing heterocyclic compounds via multicomponent reaction is
one of the preferable processes in synthetic organic chemistry and medicinal chemistry …

Azirine-containing dipeptides and depsipeptides with a wide range of substituents have
been synthesized in high yields via the Passerini and Ugi multicomponent reactions (MCRs) …

Multicomponent reactions (MCRs) are important transformations, which allow the attainment
of structurally complex derivatives in a single step, starting from three or more compounds …

Diastereoselectivity in Passerini and Ugi reactions of chiral aldehydes/imines remains
challenging. Moreover, the Ugi reaction of chiral acyclic imines is complicated by their easy …