Translating phage therapy into the clinic: Recent accomplishments but continuing challenges

A Petrovic Fabijan, J Iredell, K Danis-Wlodarczyk… - Plos …, 2023 - journals.plos.org
Phage therapy is a medical form of biological control of bacterial infections, one that uses
naturally occurring viruses, called bacteriophages or phages, as antibacterial agents …

Current therapies and challenges for the treatment of Staphylococcus aureus biofilm‐related infections

NN Tran, T Morrisette, SCJ Jorgensen… - … : The Journal of …, 2023 - Wiley Online Library
Staphylococcus aureus is a major cause of nosocomial and community‐acquired infections
and contributes to significant increase in morbidity and mortality especially when associated …

Isolation and characterization of a novel lytic bacteriophage vB_Efm_LG62 infecting Enterococcus faecium

Q Qu, T Chen, P He, H Geng, P Zeng, G Luan - Virus Genes, 2023 - Springer
Enterococcus faecium has been classified as a “high priority” pathogen by the World Health
Organization. Enterococcus faecium has rapidly evolved as a global nosocomial pathogen …

Phage-antibiotic cocktail rescues daptomycin and phage susceptibility against daptomycin-nonsusceptible Enterococcus faecium in a simulated endocardial …

AJ Kunz Coyne, K Stamper, A El Ghali… - Microbiology …, 2023 - Am Soc Microbiol
Enterococcus faecium is a difficult-to-treat pathogen with emerging resistance to most
clinically available antibiotics. Daptomycin (DAP) is the standard of care, but even high DAP …

Exploiting phage-antibiotic synergies to disrupt Pseudomonas aeruginosa PAO1 biofilms in the context of orthopedic infections

S De Soir, H Parée, NHN Kamarudin… - Microbiology …, 2024 - Am Soc Microbiol
In recent years, bacteriophages (or phages) have reentered the spotlight as alternative or
adjuvant therapeutic agents to antibiotics. Their efficacy in more recalcitrant forms of …

Synergistic bactericidal effects of phage-enhanced antibiotic therapy against MRSA biofilms

AJ Kunz Coyne, K Stamper, C Bleick… - Microbiology …, 2024 - Am Soc Microbiol
Methicillin-resistant Staphylococcus aureus (MRSA) causes biofilm-related medical device
infections. Phage-antibiotic combinations offer potential therapy due to proven in vitro …

Enterococcal phages: food and health applications

C Rodríguez-Lucas, V Ladero - Antibiotics, 2023 - mdpi.com
Enterococcus is a diverse genus of Gram-positive bacteria belonging to the lactic acid
bacteria (LAB) group. It is found in many environments, including the human gut and …

[HTML][HTML] Structural and functional features of a broad-spectrum prophage-encoded enzybiotic from Enterococcus faecium

GE Premetis, A Stathi, AC Papageorgiou… - Scientific Reports, 2023 - nature.com
Multidrug-resistant (MDR) bacteria have become a growing threat to public health. The gram-
positive Enterococcus faecium is classified by WHO as a high-priority pathogen among the …

The virtue of training: extending phage host spectra against vancomycin-resistant Enterococcus faecium strains using the Appelmans method

J Lossouarn, E Beurrier, A Bouteau… - Antimicrobial Agents …, 2024 - Am Soc Microbiol
Phage therapy has (re) emerged as a serious possibility for combating multidrug-resistant
bacterial infections, including those caused by vancomycin-resistant Enterococcus faecium …

Bacteriophage and antibiotic combination therapy for recurrent Enterococcus faecium bacteremia

ME Stellfox, C Fernandes, RK Shields, G Haidar… - Mbio, 2024 - Am Soc Microbiol
Enterococcus faecium is a member of the human gastrointestinal (GI) microbiota but can
also cause invasive infections, especially in immunocompromised hosts. Enterococci …