Neuronal K+-Cl- cotransporter KCC2 as a promising drug target for epilepsy treatment

E McMoneagle, J Zhou, S Zhang, W Huang… - Acta Pharmacologica …, 2024 - nature.com
Epilepsy is a prevalent neurological disorder characterized by unprovoked seizures. γ-
Aminobutyric acid (GABA) serves as the primary fast inhibitory neurotransmitter in the brain …

A comprehensive review of emerging trends and innovative therapies in epilepsy management

S Ghosh, JK Sinha, S Ghosh, H Sharma, R Bhaskar… - Brain Sciences, 2023 - mdpi.com
Epilepsy is a complex neurological disorder affecting millions worldwide, with a substantial
number of patients facing drug-resistant epilepsy. This comprehensive review explores …

Electroencephalogram signal classification based on Fourier transform and Pattern Recognition Network for epilepsy diagnosis

Q Gao, AH Omran, Y Baghersad, O Mohammadi… - … Applications of Artificial …, 2023 - Elsevier
Epilepsy is a central nervous system (CNS) disorder that affects nerve cells in the brain and
produces seizures in which consciousness is lost. People with epilepsy have frequent …

Deciphering the Biophysical Properties of Ion Channel Gating Pores by Coumarin–Benzodiazepine Hybrid Derivatives: Selective AMPA Receptor Antagonists

M Qneibi, M Hawash, M Gümüş, İ Çapan, Y Sert… - Molecular …, 2024 - Springer
In the 1980s, the identification of specific pharmacological antagonists played a crucial role
in enhancing our comprehension of the physiological mechanisms associated with α-amino …

Transformer's Role in Brain MRI: A Scoping Review

M Hayat, S Aramvith - IEEE Access, 2024 - ieeexplore.ieee.org
Magnetic Resonance Imaging (MRI) is a critical imaging technique that provides detailed
visualization of internal structures without harmful radiation. This review focuses on key MRI …

Pathophysiological heterogeneity of the BBSOA neurodevelopmental syndrome

M Bertacchi, C Tocco, CP Schaaf, M Studer - Cells, 2022 - mdpi.com
The formation and maturation of the human brain is regulated by highly coordinated
developmental events, such as neural cell proliferation, migration and differentiation. Any …

Apoptosis regulation by the tyrosine-protein kinase CSK

A Fortner, A Chera, A Tanca, O Bucur - Frontiers in cell and …, 2022 - frontiersin.org
C-terminal Src kinase (CSK) is a cytosolic tyrosine-protein kinase with an important role in
regulating critical cellular decisions, such as cellular apoptosis, survival, proliferation …

Sleep deprivation: a risk for epileptic seizures

JT Dell'Aquila, V Soti - Sleep Science, 2022 - thieme-connect.com
There is a well-documented correlation between epilepsy and sleep deprivation. For
decades, preclinical and clinical studies have shown that sleep deprivation can lead to an …

Circular RNA SLC8A1 triggers hippocampal neuronal ferroptosis by regulating FUS-mediated ATF3 mRNA stability in epilepsy

Q Kang, J Zhang, C Xie, S Fang, W Chai - Experimental Cell Research, 2024 - Elsevier
Background Epilepsy is a neurological disorder characterized by recurrent seizures and is
often unresponsive to current treatment options. Ferroptosis, a recently defined iron …

[HTML][HTML] The neuromorphic computing for biointegrated electronics

SJ Yoon, JT Park, YK Lee - Soft Science, 2024 - oaepublish.com
This review investigates the transformative potential of neuromorphic computing in
advancing biointegrated electronics, with a particular emphasis on applications in medical …