The human immunodeficiency virus type 1 (HIV-1) trans-activator of transcription protein Tat
is an important factor in viral pathogenesis. In addition to its function as the key trans …

Over the past 20 years most of the efforts in HIV vaccine development have focused on
sterilizing immunity by targeting the Envelope protein (Env). However, results from …

Vaccine strategies aimed at blocking virus entry have so far failed to induce protection
against heterologous viruses. Thus, the control of viral infection and the block of disease …

Vaccination of cynomolgus monkeys with the biologically active HIV-1 Tat protein induces
specific Th1 responses, including CTLs. Similar responses are also induced by vaccination …

ABSTRACT DNA vaccines have been successful in eliciting potent immune responses in
mice. Their efficiency, however, is restricted in larger animals. One reason for the limited …

Vaccination with a biologically active Tat protein or tat DNA contained infection with the
highly pathogenic SHIV89. 6P virus, preventing CD4 T-cell decline and disease onset. Here …

Since the first descriptions of HIV/AIDS, HIV-1 has emerged as the most significant pathogen
worldwide, with approaching 60 million infections to the end of 2000. Over 18 million deaths …

Electroporation can improve intramuscular DNA vaccination efficacy but the exact antigen
presentation mechanism remains unclear. We reported here that a similar immuno …

Tat is an early regulatory protein that plays a major role in human HIV-1 replication and
AIDS pathogenesis, and therefore, it represents a key target for the host immune response …

Human herpesvirus 6 (HHV-6) is the only human herpesvirus encoding U94/rep, homologue
to the parvovirus non-structural gene rep68/78. Results to date suggest that HHV-6 U94/rep …