Deformability of the plasma membrane, the outermost surface of metazoan cells, allows cells
to be dynamic, mobile and flexible. Factors that affect this deformability, such as tension on …

One of the fundamental features of biomembranes is the ability to fuse or to separate. These
processes called respectively membrane fusion and fission are central in the homeostasis of …

The vast majority of cell biological studies examine function and molecular mechanisms
using cells on flat surfaces: glass, plastic and more recently elastomeric polymers. While …

Store-operated Ca2+ entry (SOCE) is the major route of Ca2+ influx in platelets. The Ca2+
sensor stromal interaction molecule 1 (STIM1) triggers SOCE by forming punctate structures …

Background Nutrient stress-responsive neuronal homeostasis relies on intricate autophagic
mechanisms that modulate various organelle integrity and function. The selective autophagy …

The Cdk8 kinase module (CKM) of the multi-subunit mediator complex plays an essential
role in cell fate decisions in response to different environmental cues. In the budding yeast …

Dendrites are the input compartment of the neuron, receiving and integrating incoming
information. Dendritic trees are often highly complex and branched. Their branch extension …

Autophagy, in part, is controlled by the repression and activation of autophagy-related (ATG)
genes. Here, we describe a new selective autophagy pathway that targets functional …

Lipid membranes form the boundary of many biological compartments, including organelles
and cells. Consisting of two leaflets of amphipathic molecules, the bilayer membrane forms …

ASAP1 is a multi-domain ArfGAP that controls cell migration, spreading, and focal adhesion
dynamics. Although its GAP activity contributes to remodeling of the actin cytoskeleton, it …