[HTML][HTML] Akkermansia muciniphila in the human gastrointestinal tract: when, where, and how?

SY Geerlings, I Kostopoulos, WM De Vos, C Belzer - Microorganisms, 2018 - mdpi.com
Akkermansia muciniphila is a mucin-degrading bacterium of the phylum Verrucomicrobia. Its
abundance in the human intestinal tract is inversely correlated to several disease states. A …

Transformer hydrogels: a review

O Erol, A Pantula, W Liu… - Advanced Materials …, 2019 - Wiley Online Library
Hydrogels, which are hydrophilic soft porous networks, are an important class of materials of
broad relevance to bioanalytical chemistry, soft‐robotics, drug delivery, and regenerative …

Gut microbiota and iron: the crucial actors in health and disease

B Yilmaz, H Li - Pharmaceuticals, 2018 - mdpi.com
Iron (Fe) is a highly ample metal on planet earth (~ 35% of the Earth's mass) and is
particularly essential for most life forms, including from bacteria to mammals. Nonetheless …

The role of mucus on drug transport and its potential to affect therapeutic outcomes

X Murgia, B Loretz, O Hartwig, M Hittinger… - Advanced drug delivery …, 2018 - Elsevier
A layer of mucus covers the surface of all wet epithelia throughout the human body. Mucus is
a hydrogel mainly composed of water, mucins (glycoproteins), DNA, proteins, lipids, and cell …

Acylated anthocyanins: A review on their bioavailability and effects on postprandial carbohydrate metabolism and inflammation

J Jokioja, B Yang, KM Linderborg - Comprehensive Reviews in …, 2021 - Wiley Online Library
Anthocyanins, the natural red and purple colorants of berries, fruits, vegetables, and tubers,
improve carbohydrate metabolism and decrease the risk factors of metabolic disorders, but …

Upper gastrointestinal (GI) pH in young, healthy men and women

JB Dressman, RR Berardi, LC Dermentzoglou… - Pharmaceutical …, 1990 - Springer
The pH in the upper gastrointestinal tract of young, healthy men and women was measured
in the fasting state and after administration of a standard solid and liquid meal. Calibrated …

Physiological Parameters for Oral Delivery and in Vitro Testing

DM Mudie, GL Amidon, GE Amidon - Molecular pharmaceutics, 2010 - ACS Publications
Pharmaceutical solid oral dosage forms must undergo dissolution in the intestinal fluids of
the gastrointestinal tract before they can be absorbed and reach the systemic circulation …

Influence of physicochemical properties on dissolution of drugs in the gastrointestinal tract

D Hörter, JB Dressman - Advanced drug delivery reviews, 2001 - Elsevier
The rate-limiting step to absorption of drugs from the gastrointestinal (GI) tract is often
dissolution from the dosage form. Consideration of the Noyes-Whitney dissolution model …

Gastroduodenal mucus bicarbonate barrier: protection against acid and pepsin

A Allen, G Flemström - American Journal of Physiology …, 2005 - journals.physiology.org
Secretion of bicarbonate into the adherent layer of mucus gel creates a pH gradient with a
near-neutral pH at the epithelial surfaces in stomach and duodenum, providing the first line …

Characterization of the human upper gastrointestinal contents under conditions simulating bioavailability/bioequivalence studies

L Kalantzi, K Goumas, V Kalioras… - Pharmaceutical …, 2006 - Springer
Purpose This study was conducted to compare the luminal composition of the upper
gastrointestinal tract in the fasted and fed states in humans, with a view toward designing in …