Nature has evolved halogenase enzymes to regioselectively halogenate a diverse range of
biosynthetic precursors, with the halogens introduced often having a profound effect on the …

Flavoprotein monooxygenases (FPMOs) are single-or two-component enzymes that
catalyze a diverse set of chemo-, regio-and enantioselective oxyfunctionalization reactions …

Oxygenases-catalyzed reductive activation of molecular oxygen and incorporation of O
atoms into an organic molecule is undoubtedly one of the most attractive research areas …

The search for affordable, green biocatalytic processes is a challenge for chemicals
manufacture. Redox biotransformations are potentially attractive, but they rely on unstable …

Biological production of chemicals often requires the use of cellular cofactors, such as
nicotinamide adenine dinucleotide phosphate (NADP+). These cofactors are expensive to …

Monooxygenases are promising catalysts because they in principle enable the organic
chemist to perform highly selective oxyfunctionalisation reactions that are otherwise difficult …

Biocatalytic cascades are a powerful tool for building complex molecules containing oxygen
and nitrogen functionalities. Moreover, the combination of multiple enzymes in one pot offers …

Flavoprotein monooxygenases create valuable compounds that are of high interest for the
chemical, pharmaceutical, and agrochemical industries, among others. Monooxygenases …

Catalytic stereoselective desymmetrization of prochiral compounds to valuable chiral
molecules is of interest in asymmetric synthesis. Here, we report the development of an …

NADH mimics (mNADHs) have been shown to accelerate and orthogonally activate ene
reductase-catalyzed reactions. However, existing regeneration methods of NAD (P) H fail for …