Cellular and molecular pathobiology of heart failure with preserved ejection fraction
Heart failure with preserved ejection fraction (HFpEF) affects half of all patients with heart
failure worldwide, is increasing in prevalence, confers substantial morbidity and mortality …
failure worldwide, is increasing in prevalence, confers substantial morbidity and mortality …
Evaluation and management of heart failure with preserved ejection fraction
BA Borlaug - Nature Reviews Cardiology, 2020 - nature.com
Heart failure with preserved ejection fraction (HFpEF) has grown to become the dominant
form of heart failure worldwide, in tandem with ageing of the general population and the …
form of heart failure worldwide, in tandem with ageing of the general population and the …
Targeting the NLRP3 inflammasome in cardiovascular diseases
The NACHT, leucine-rich repeat (LRR), and pyrin domain (PYD)-containing protein 3
(NLRP3) inflammasome is an intracellular sensing protein complex that plays a major role in …
(NLRP3) inflammasome is an intracellular sensing protein complex that plays a major role in …
From systemic inflammation to myocardial fibrosis: the heart failure with preserved ejection fraction paradigm revisited
WJ Paulus, MR Zile - Circulation Research, 2021 - Am Heart Assoc
In accordance with the comorbidity-inflammation paradigm, comorbidities and especially
metabolic comorbidities are presumed to drive development and severity of heart failure with …
metabolic comorbidities are presumed to drive development and severity of heart failure with …
Inflammatory cytokines and chemokines as therapeutic targets in heart failure
A Hanna, NG Frangogiannis - Cardiovascular Drugs and Therapy, 2020 - Springer
Heart failure exhibits remarkable pathophysiologic heterogeneity. A large body of evidence
suggests that regardless of the underlying etiology, heart failure is associated with induction …
suggests that regardless of the underlying etiology, heart failure is associated with induction …
Interleukin-1 and the inflammasome as therapeutic targets in cardiovascular disease
The intracellular sensing protein termed NLRP3 (for NACHT, LRR, and PYD domains-
containing protein 3) forms a macromolecular structure called the NLRP3 inflammasome …
containing protein 3) forms a macromolecular structure called the NLRP3 inflammasome …
Obesity paradox in cardiovascular disease: where do we stand?
Obesity is associated with an increased risk of developing cardiovascular disease (CVD),
particularly heart failure (HF) and coronary heart disease (CHD). The mechanisms through …
particularly heart failure (HF) and coronary heart disease (CHD). The mechanisms through …
The role of the NLRP3 inflammasome and pyroptosis in cardiovascular diseases
An intense, stereotyped inflammatory response occurs in response to ischaemic and non-
ischaemic injury to the myocardium. The NACHT, LRR and PYD domains-containing protein …
ischaemic injury to the myocardium. The NACHT, LRR and PYD domains-containing protein …
Heart failure with preserved ejection fraction: from mechanisms to therapies
This review aims to provide a translational perspective on recent developments in heart
failure with preserved ejection fraction (HFpEF), linking mechanistic insights to potential …
failure with preserved ejection fraction (HFpEF), linking mechanistic insights to potential …
Exercise Intolerance in Older Adults With Heart Failure With Preserved Ejection Fraction: JACC State-of-the-Art Review
Exercise intolerance (EI) is the primary manifestation of chronic heart failure with preserved
ejection fraction (HFpEF), the most common form of heart failure among older individuals …
ejection fraction (HFpEF), the most common form of heart failure among older individuals …