The EGFR family: not so prototypical receptor tyrosine kinases
MA Lemmon, J Schlessinger… - Cold Spring Harbor …, 2014 - cshperspectives.cshlp.org
The epidermal growth factor receptor (EGFR) was among the first receptor tyrosine kinases
(RTKs) for which ligand binding was studied and for which the importance of ligand-induced …
(RTKs) for which ligand binding was studied and for which the importance of ligand-induced …
[HTML][HTML] Endothelial Ca2+ Signaling, Angiogenesis and Vasculogenesis: Just What It Takes to Make a Blood Vessel
It has long been known that endothelial Ca2+ signals drive angiogenesis by recruiting
multiple Ca2+-sensitive decoders in response to pro-angiogenic cues, such as vascular …
multiple Ca2+-sensitive decoders in response to pro-angiogenic cues, such as vascular …
Critical functions of the lysosome in cancer biology
SM Davidson, MG Vander Heiden - Annual review of …, 2017 - annualreviews.org
Lysosomes (or lytic bodies) were so named because they contain high levels of hydrolytic
enzymes. Lysosome function and dysfunction have been found to play important roles in …
enzymes. Lysosome function and dysfunction have been found to play important roles in …
[HTML][HTML] Kinetics of mRNA delivery and protein translation in dendritic cells using lipid-coated PLGA nanoparticles
H Yasar, A Biehl, C De Rossi, M Koch, X Murgia… - Journal of …, 2018 - Springer
Abstract Background Messenger RNA (mRNA) has gained remarkable attention as an
alternative to DNA-based therapies in biomedical research. A variety of biodegradable …
alternative to DNA-based therapies in biomedical research. A variety of biodegradable …
Enhanced dimerization drives ligand-independent activity of mutant epidermal growth factor receptor in lung cancer
Mutations within the epidermal growth factor receptor (EGFR/erbB1/Her1) are often
associated with tumorigenesis. In particular, a number of EGFR mutants that demonstrate …
associated with tumorigenesis. In particular, a number of EGFR mutants that demonstrate …
Graphene liquid enclosure for single-molecule analysis of membrane proteins in whole cells using electron microscopy
Membrane proteins govern many important functions in cells via dynamic oligomerization
into active complexes. However, analytical methods to study their distribution and functional …
into active complexes. However, analytical methods to study their distribution and functional …
[HTML][HTML] Plasma membrane organization of epidermal growth factor receptor in resting and ligand-bound states
The spatial arrangement of the epidermal growth factor receptor (EGFR) on the cellular
plasma membrane is one of the prime factors that control its downstream signaling pathways …
plasma membrane is one of the prime factors that control its downstream signaling pathways …
Putting together structures of epidermal growth factor receptors
NJ Bessman, DM Freed, MA Lemmon - Current opinion in structural biology, 2014 - Elsevier
Highlights•Several studies suggest flexible linkage between extracellular and intracellular
regions.•Others imply more rigid connections, required for allosteric regulation of …
regions.•Others imply more rigid connections, required for allosteric regulation of …
MYO1D binds with kinase domain of the EGFR family to anchor them to plasma membrane before their activation and contributes carcinogenesis
The cell surface receptor tyrosine kinase (RTK) exists in a dynamic state, however, it
remains unknown how single membrane-spanning RTK proteins are retained in the plasma …
remains unknown how single membrane-spanning RTK proteins are retained in the plasma …
[HTML][HTML] Inhibition of receptor dimerization as a novel negative feedback mechanism of EGFR signaling
Dimerization of the epidermal growth factor receptor (EGFR) is crucial for initiating signal
transduction. We employed raster image correlation spectroscopy to continuously monitor …
transduction. We employed raster image correlation spectroscopy to continuously monitor …