Covering: 2000 to 2017 Cytochrome P450 enzymes (P450s) are the most versatile
biocatalysts in nature. The catalytic competence of these extraordinary hemoproteins is …

Natural products continue to play a pivotal role in drug-discovery efforts and in the
understanding of human health. The ability to extend nature's chemistry through …

Protein complexes of the mitochondrial respiratory chain assemble into respiratory
supercomplexes. Here we present the high-resolution electron cryo-microscopy structure of …

Synthetic biology offers the opportunity to build solutions for improved capture and
conversion of carbon dioxide (CO2) that outcompete those evolved by nature. Here we …

Although natural products and synthetic small molecules both serve important medicinal
functions, their structures and chemical properties are relatively distinct. To expand the …

Covering: up to May 2012The β-lactam antibiotics and related β-lactamase inhibitors are
amongst the most important small molecules in clinical use. Most, but not all, β-lactams …

Covering: up to 2015 Multienzyme polyketide synthases (PKSs) are molecular-scale
assembly lines which construct complex natural products in bacteria. The underlying …

Methylotrophy is the ability to use reduced one-carbon compounds, such as methanol, as a
single source of carbon and energy. Methanol is, due to its availability and potential for …

A subset of natural products, such as polyketides and nonribosomal peptides, is
biosynthesized while tethered to a carrier peptide via a thioester linkage. Recently, we …

Type I modular polyketide synthases (PKSs) are polymerases that utilize acyl-CoAs as
substrates. Each polyketide elongation reaction is catalyzed by a set of protein domains …