Nicotinamide adenine dinucleotide (NAD), the cell's hydrogen carrier for redox enzymes, is
well known for its role in redox reactions. More recently, it has emerged as a signaling …

In contrast to the multiple disease-modifying therapies that are available for relapsing–
remitting multiple sclerosis (MS), the therapeutic options for progressive MS (PMS) are …

Wallerian degeneration is a widespread mechanism of programmed axon degeneration. In
the three decades since the discovery of the Wallerian degeneration slow (Wld S) mouse …

The role in longevity and healthspan of nicotinamide (NAM), the physiological precursor of
NAD+, is elusive. Here, we report that chronic NAM supplementation improves healthspan …

Multiple sclerosis (MS) is the most frequent chronic inflammatory disease of the CNS, and
imposes major burdens on young lives. Great progress has been made in understanding …

Axon degeneration is a prominent early feature of most neurodegenerative disorders and
can also be induced directly by nerve injury in a process known as Wallerian degeneration …

Multiple sclerosis (MS) and neuromyelitis optica (NMO) are autoimmune demyelinating
diseases of the central nervous system (CNS), having distinct immunological and …

C. NADP synthesis D. Catabolism of NAD and NADP E. Relationships between NAD and
NADP F. NAD transport across mitochondrial membranes G. NAD transport across the …

The rapidly evolving therapeutic landscape of multiple sclerosis (MS) has contributed to
paradigm shifts in our understanding of the biological mechanisms that contribute to CNS …

Intense noise exposure causes hearing loss by inducing degeneration of spiral ganglia
neurites that innervate cochlear hair cells. Nicotinamide adenine dinucleotide (NAD+) …