International Union of Pharmacology LVIII: update on the P2Y G protein-coupled nucleotide receptors: from molecular mechanisms and pathophysiology to therapy
MP Abbracchio, G Burnstock… - Pharmacological …, 2006 - pharmrev.aspetjournals.org
There have been many advances in our knowledge about different aspects of P2Y receptor
signaling since the last review published by our International Union of Pharmacology …
signaling since the last review published by our International Union of Pharmacology …
Purinergic signaling and blood vessels in health and disease
G Burnstock, V Ralevic - Pharmacological reviews, 2014 - ASPET
Purinergic signaling plays important roles in control of vascular tone and remodeling. There
is dual control of vascular tone by ATP released as a cotransmitter with noradrenaline from …
is dual control of vascular tone by ATP released as a cotransmitter with noradrenaline from …
Coupling of P2Y receptors to G proteins and other signaling pathways
L Erb, GA Weisman - Wiley Interdisciplinary Reviews …, 2012 - Wiley Online Library
Abstract P2Y receptors are G protein‐coupled receptors (GPCRs) that are activated by
adenine and uridine nucleotides and nucleotide sugars. There are eight subtypes of P2Y …
adenine and uridine nucleotides and nucleotide sugars. There are eight subtypes of P2Y …
P2 receptors in cardiovascular regulation and disease
D Erlinge, G Burnstock - Purinergic signalling, 2008 - Springer
The role of ATP as an extracellular signalling molecule is now well established and
evidence is accumulating that ATP and other nucleotides (ADP, UTP and UDP) play …
evidence is accumulating that ATP and other nucleotides (ADP, UTP and UDP) play …
NTPDase and 5'‐nucleotidase activities in physiological and disease conditions: New perspectives for human health
Extracellular nucleotides and nucleosides act as signaling molecules involved in a wide
spectrum of biological effects. Their levels are controlled by a complex cell surface‐located …
spectrum of biological effects. Their levels are controlled by a complex cell surface‐located …
P2 receptors: intracellular signaling
P2 receptors for extracellular nucleotides are divided into two categories: the ion channel
receptors (P2X) and the G-protein-coupled receptors (P2Y). For the P2X receptors, signal …
receptors (P2X) and the G-protein-coupled receptors (P2Y). For the P2X receptors, signal …
Src homology 3 binding sites in the P2Y2 nucleotide receptor interact with Src and regulate activities of Src, proline-rich tyrosine kinase 2, and growth factor receptors
J Liu, Z Liao, J Camden, KD Griffin, RC Garrad… - Journal of Biological …, 2004 - ASBMB
Many G protein-coupled receptors activate growth factor receptors, although the
mechanisms controlling this transactivation are unclear. We have identified two proline-rich …
mechanisms controlling this transactivation are unclear. We have identified two proline-rich …
[图书][B] Purinergic signalling and the nervous system
G Burnstock, V Alexei - 2012 - books.google.com
In the first 20 years that followed the purinergic signalling hypothesis in 1972, most scientists
were sceptical about its validity, largely because ATP was so well established as an …
were sceptical about its validity, largely because ATP was so well established as an …
P2 receptors activated by uracil nucleotides-an update
A Brunschweiger, CE Muller - Current medicinal chemistry, 2006 - ingentaconnect.com
Pyrimidine nucleotides, including UTP, UDP and UDP-glucose, are important signaling
molecules which activate G protein-coupled membrane receptors (GPCRs) of the P2Y …
molecules which activate G protein-coupled membrane receptors (GPCRs) of the P2Y …
The P2Y2 nucleotide receptor mediates vascular cell adhesion molecule-1 expression through interaction with VEGF receptor-2 (KDR/Flk-1)
UTP stimulates the expression of pro-inflammatory vascular cell adhesion molecule-1
(VCAM-1) in endothelial cells through activation of the P2Y 2 nucleotide receptor P2Y 2 R …
(VCAM-1) in endothelial cells through activation of the P2Y 2 nucleotide receptor P2Y 2 R …