The β-propeller is a highly symmetrical structure with 4–10 repeats of a four-stranded
antiparallel β-sheet motif. Although β-propeller proteins with different blade numbers all …

Pyroglutamate (pE) modification, catalyzed mainly by glutaminyl cyclase (QC), is prevalent
throughout nature and is particularly important in mammals including humans for the …

Glutaminyl cyclase (QC) modifies N-terminal glutamine or glutamic acid residues of target
proteins into cyclic pyroglutamic acid (pGlu). Here, we report the biochemical and functional …

Latrophilins, receptors for spider venom α-latrotoxin, are adhesion type G-protein-coupled
receptors with emerging functions in synapse development. The N-terminal region binds the …

Olfactomedin (OLF) domain-containing proteins play roles in fundamental cellular processes
and have been implicated in disorders ranging from glaucoma, cancers and inflammatory …

Hand-in-hand work of physics and evolution delivered protein universe with diversity of
forms, sizes, and functions. Pervasiveness and advantageous traits of allostery made it an …

Aberrant pyroglutamate formation at the N terminus of certain peptides and proteins,
catalyzed by glutaminyl cyclases (QCs), is linked to some pathological conditions, such as …

The trypanosomatids Trypanosoma cruzi, Leishmania spp. and Trypanosoma brucei spp.
cause Chagas disease, leishmaniasis and human African trypanosomiasis, respectively. It is …

The development of a targeted therapy would significantly improve the treatment of
periodontitis and its associated diseases including Alzheimer's disease, rheumatoid arthritis …

Bacteroidetes feature prominently in the human microbiome, as major colonizers of the gut
and clinically relevant pathogens elsewhere. Here, we reveal a new Bacteroidetes specific …