BACKGROUND Obesity has now been recognized as a high-risk factor for reproductive
health. Although remarkable advancements have been made in ART, a considerable …

At implantation, with the acquisition of a receptive phenotype in the uterine epithelium, an
initial tenuous attachment of embryonic trophectoderm initiates reorganisation of epithelial …

The initiation of human pregnancy is marked by the implantation of an embryo into the
uterine environment; however, the underlying mechanisms remain largely elusive. To …

BACKGROUND The embryo implantation process is crucial for the correct establishment
and progress of pregnancy. During implantation, the blastocyst trophectoderm cells attach to …

STUDY QUESTION How does the human embryo breach the endometrial epithelium at
implantation? SUMMARY ANSWER Embryo attachment to the endometrial epithelium …

Selective progesterone receptor modulators (SPRMs) are a new class of compounds
developed to target the progesterone receptor (PR) with a mix of agonist and antagonist …

Progesterone is required for the establishment and maintenance of mammalian pregnancy
and widely used for conservative treatment of luteal phase deficiency in clinics. However …

STUDY QUESTION Does embryo transfer medium containing hyaluronate (HA) promote the
attachment phase of human embryo implantation? SUMMARY ANSWER HA-containing …

STUDY QUESTION What are the changes in human embryos, in terms of morphology and
gene expression, upon attachment to endometrial epithelial cells? SUMMARY ANSWER …

Objective To establish a model of human implantation that responds to hormonal stimuli and
can differentiate between endometrium from fertile women and those with idiopathic …