Molecular signatures underlying neurofibrillary tangle susceptibility in Alzheimer's disease
Tau aggregation in neurofibrillary tangles (NFTs) is closely associated with
neurodegeneration and cognitive decline in Alzheimer's disease (AD). However, the …
neurodegeneration and cognitive decline in Alzheimer's disease (AD). However, the …
RNA dynamics in Alzheimer's disease
A Rybak-Wolf, M Plass - Molecules, 2021 - mdpi.com
Alzheimer's disease (AD) is the most common age-related neurodegenerative disorder that
heavily burdens healthcare systems worldwide. There is a significant requirement to …
heavily burdens healthcare systems worldwide. There is a significant requirement to …
Development of dementia in type 2 diabetes patients: mechanisms of insulin resistance and antidiabetic drug development
Dementia is reported to be common in those with type 2 diabetes mellitus. Type 2 diabetes
contributes to common molecular mechanisms and an underlying pathology with dementia …
contributes to common molecular mechanisms and an underlying pathology with dementia …
Stem cell-derived neurons reflect features of protein networks, neuropathology, and cognitive outcome of their aged human donors
We have generated a controlled and manipulable resource that captures genetic risk for
Alzheimer's disease: iPSC lines from 53 individuals coupled with RNA and proteomic …
Alzheimer's disease: iPSC lines from 53 individuals coupled with RNA and proteomic …
Functional regulatory variants implicate distinct transcriptional networks in dementia
Predicting the function of noncoding variation is a major challenge in modern genetics. In
this study, we used massively parallel reporter assays to screen 5706 variants identified …
this study, we used massively parallel reporter assays to screen 5706 variants identified …
[HTML][HTML] Integrated multi-omics analysis reveals the underlying molecular mechanism for developmental neurotoxicity of perfluorooctanesulfonic acid in zebrafish
Limited studies on multi-omics have been conducted to comprehensively investigate the
molecular mechanism underlying the developmental neurotoxicity of …
molecular mechanism underlying the developmental neurotoxicity of …
STAMarker: determining spatial domain-specific variable genes with saliency maps in deep learning
Spatial transcriptomics characterizes gene expression profiles while retaining the
information of the spatial context, providing an unprecedented opportunity to understand …
information of the spatial context, providing an unprecedented opportunity to understand …
Protein mishandling and impaired lysosomal proteolysis generated through calcium dysregulation in Alzheimer's disease
S Mustaly-Kalimi, W Gallegos… - Proceedings of the …, 2022 - National Acad Sciences
Impairments in neural lysosomal-and autophagic-mediated degradation of cellular debris
contribute to neuritic dystrophy and synaptic loss. While these are well-characterized …
contribute to neuritic dystrophy and synaptic loss. While these are well-characterized …
Differential transcript usage unravels gene expression alterations in Alzheimer's disease human brains
D Marques-Coelho, LCC Iohan… - npj Aging and …, 2021 - nature.com
Alzheimer's disease (AD) is the leading cause of dementia in aging individuals. Yet, the
pathophysiological processes involved in AD onset and progression are still poorly …
pathophysiological processes involved in AD onset and progression are still poorly …
Pulse-chase proteomics of the App knockin mouse models of Alzheimer's disease reveals that synaptic dysfunction originates in presynaptic terminals
TJ Hark, NR Rao, C Castillon, T Basta, S Smukowski… - Cell systems, 2021 - cell.com
Compromised protein homeostasis underlies accumulation of plaques and tangles in
Alzheimer's disease (AD). To observe protein turnover at early stages of amyloid beta (Aβ) …
Alzheimer's disease (AD). To observe protein turnover at early stages of amyloid beta (Aβ) …