Vascular endothelial cells form the inner layer of blood vessels where they have a key role
in the development and maintenance of the functional circulatory system and provide …

All organisms growing beyond the oxygen diffusion limit critically depend on a functional
vasculature for survival. Yet blood vessels are far more than passive, uniform conduits for …

The CXCR4 receptor upon binding its ligands triggers multiple signaling pathways that
orchestrate cell migration, hematopoiesis and cell homing, and retention in the bone …

Endothelial-to-mesenchymal transition is a dynamic process in which endothelial cells
suppress constituent endothelial properties and take on mesenchymal cell behaviors. To …

The adult mammalian heart has limited capacity for regeneration following injury, whereas
the neonatal heart can readily regenerate within a short period after birth. Neonatal heart …

The heart is lined by a single layer of mesothelial cells called the epicardium that provides
important cellular contributions for embryonic heart formation. The epicardium harbors a …

Cardiomyocyte loss after injury results in adverse remodelling and fibrosis, inevitably
leading to heart failure. The ERBB2–Neuregulin and Hippo–YAP signalling pathways are …

1164 Circulation Research April 12, 2019 blocked the EndMT and fibrotic markers and
reduced migration of TGFβ-treated valve endothelial cells. CD45 is not normally expressed …

Background: Neonatal mouse cardiomyocytes undergo a metabolic switch from glycolysis to
oxidative phosphorylation, which results in a significant increase in reactive oxygen species …

Heart regenerative medicine has been gradually evolving from a view of the heart as a
nonregenerative organ with terminally differentiated cardiac muscle cells. Understanding the …